When Mechanistic IVIVC Falls Short: The Case for IVIVR in Oral Drug Delivery

Authors: Mullin JM
Conference: CRS
Keywords: admet predictor, gastroplus, In vitro in vivo correlations (IVIVC), In vitro–in vivo relationship (IVIVR), oral drug delivery, pbbm
Software: ADMET Predictor®, GastroPlus®

Introduction

  • Traditional IVIVC
  • Utilizing IVIVR and PBBM
    • Benefits
    • Dissolution modeling
  • Case Studies
    • IVIVR and z-factor dissolution
    • Product specific particle size distribution (PPSD) safe space

By James Mullin

CRS 2025 Annual Meeting & Expo Philidelphia, PA, July 13-18, 2025