Description
Learn how to leverage DDDPlus™ to simulate and predict dissolution behavior across a variety of formulation scenarios. This course covers key concepts including solubility versus pH, particle size effects, biorelevant solubility, precipitation modeling, extended-release formulations, surfactant media dissolution, and the role of disintegration or solubilizer constants—empowering scientists to use in silico tools for optimizing drug product performance.
Introduction
Explore DDDPlus to model various dissolution processes. Study solubility-pH relationships, particle size effects, precipitation, extended-release behavior, and surfactant media. Examine disintegration and solubilizer constants. Gain powerful in silico tools to simulate complex dissolution profiles. You must have access to DDDPlus, and the course recommends a GastroPlus® license.
Topics Include
Get to Know DDD+
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Introduction
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File Menu
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Interface Tabs
Solubility vs pH
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Basic Solubility vs pH Profiles
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Fitting Solubility vs pH Profiles
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Bile Salt Effect & Solubilization
Particle Size and Biorelevant Solubility
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Overview
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Background Info & Setting Up Properties
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Hammer Milled Water
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Hammer Milled FaSSIF and FeSSIF
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Optimization
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Summary
Precipitation Modeling
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Overview & Precipitation Model Options
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AZD0865 Single & Mult. First Order
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AZD0865 MNG Model
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Summary
Extended-Release Dissolution Modeling
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Introduction
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Activity: Controlled Release
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Optimization Process
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Virtual Trials Functionality
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What is an IVIVC
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Case Study: Valproate BE Dissolution Variability
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Conclusion
Modeling Dissolution in Surfactant Media
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Introduction
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Example Fenofibrate Dissolution in SLS
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Surfactant Solubility Data
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Fit Surfactant Solubility Constant; Use to Make Predictions & Summary
Dissolution with Disintegration or Solubilizer Constants
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Introduction
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Example: Dissolution of Carbamazepine with PVP Solubilizer
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Example: Dissolution of Coated Tablet with Disintegration
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Conclusions
