Simulations Plus

Earnings Up 17.7%, Shareholder Equity Up 29.4% Over Previous Fiscal Year

Up to $2.5 million over 12 months authorized by board of directors

Companies to Cooperate on Development of Advanced Ocular Delivery Simulation

Adds Property Prediction Software to Earlier GastroPlus(™) Licenses

Chemical Genomics Center Renews Five Licenses

Collaboration to Develop Drug-Drug Interaction Capability in GastroPlus™

"Conversa(™)" System Offers 12-inch Touch Tablet With Superior Voice Quality And Volume

Record revenues achieved in both business units

Conference Call to be on Tuesday, July 15, at 4:15 PM EDT

ADMET Predictor™ 3.0 Employs New Technology for Molecular Descriptors, All New Predictive Models

Agency Licenses Both Toxicity and New Enslein Metabolism Modules

ClassPharmer™ 4.5 Adds Powerful New Capabilities for Drug Molecule Design and Data Mining

Pfizer Study Presented at International Society for the Study of Xenobiotics (ISSX) Meeting in Shanghai

Version 6.0 Incorporates Major Upgrades to Several Modules, Additional User Conveniences

Company Adds Parsippany, NJ Site to Multi-year Agreement

Revenues Up 4.3%, and Earnings Up 9.0% for First 6 Months of FY2008

Conference Call to Be on Tuesday, April 15, at 4:15 PM EDT