The aim of this tutorial is to show how to develop a pharmacokinetic-pharmacodynamic (PKPD) model. It is based on a clinical study of a hypothetical test drug used in the treatment of immunosuppression and as an anti-inflammatory agent. Three different approaches are described in detail: sequential, simultaneous (joint) and intermediate (population sequential). This case study is part of the Pharmacometrics web-based learning resource from the center for translational medicine of the University of Maryland