Schiff bases of 4-Phenyl-2-Aminothiazoles as hits to new antischistosomals: Synthesis, in vitro, in vivo and in silico studies

Schiff bases of 4-Phenyl-2-Aminothiazoles as hits to new antischistosomals: Synthesis, in vitro, in vivo and in silico studies

Publication: Eur J Pharm Sci

The treatment of schistosomiasis is based on a single drug, the praziquantel (PZQ), an oral bioavailable and efficient agent which causes minimal side effects.

Application of structural and functional pharmacokinetic analogs for physiologically based pharmacokinetic model development and evaluation

Application of structural and functional pharmacokinetic analogs for physiologically based pharmacokinetic model development and evaluation

Authors: Ellison CA, Wu S
Publication: Regul Toxicol Pharmacol
Software: GastroPlus®

This work provides case studies for the pharmacokinetic (PK) analog approach, where a physiologically based pharmacokinetic (PBPK) model for a...

Absorption, distribution, metabolism, excretion, and toxicity evaluation of Papua red fruit flavonoids through a computational study

Absorption, distribution, metabolism, excretion, and toxicity evaluation of Papua red fruit flavonoids through a computational study

Publication: IOP Conf Ser Earth Environ Sci
Software: ADMET Predictor®

Red Fruit (RF) (Pandanus conoideus Lam.) was used as traditional medicine for Papuans and consumed as a daily meal.