Simulations Plus

Thales uses a standardized syntax to describe reaction kinetics, state transitions, and differential equations. This clarity reduces ambiguity, simplifying model sharing, peer review, and collaborative enhancements.

Build your model with modular components tailored for pathways, drug kinetics, and population variability. Thales’ reusable modules let you easily adapt and extend your work across diverse projects.

Simulations Plus has a growing library of pre-built Thales QSP models that can be customized, extended, and augmented as you see fit.

Embrace the complexity of inter-individual variability. Thales handles virtual populations as first-class citizens, enabling you to model diverse patient subpopulations, capture the nuances of personalized therapeutic simulations, and improve predictions of drug responses.

An additional feature of the population-centric capabilities is that Thales empowers new users to seamlessly set up patient pipelines that precisely emulate clinical trial protocols, accelerating the transition from research design to real-world application.

With our license-ready QSP models, Thales’ simulation pipelines are structured to emulate specific clinical trial designs. This includes modeling treatment schedules, dosing regimens, and inclusion/exclusion criteria so each simulated patient follows the exact protocol of an actual trial that is supported by the license ready model.

Thales includes a built-in universal optimization algorithm to calibrate model parameters using available data. By automatically adjusting parameters to minimize discrepancies between model outputs and observed data while also respecting priors, Thales ensures that the simulations accurately reflect real-world behaviors.

Refine your models with integrated sensitivity analysis. Evaluate the impact of parameters, iterate confidently, and achieve a deeper understanding of your system’s dynamics.

Every component of your model is explicitly detailed, making your work fully transparent, accessible, and reproducible. Enhance collaborative efforts by sharing projects with other Thales users in your organization and ensure long-term maintainability with thorough, built-in documentation.

Share, export, and import models in a consistent format that promotes collaboration across research groups. Thales’ commitment to standardization ensures that your models are robust, reproducible, and regulatory-ready.

• Model output plotting: Thales allows interactive plotting of all model outputs and data
• Version control: Thales stores records of prior versions of models and histories of fits and predictions
• Model & job sharing: users have private modeling sandboxes but can share models with collaborators
• Centralized job management: a single interface provides access to most Thales tools
• Distributed compute infrastructure hosting: jobs launched through the interface automatically use SLP’s distributed computing cluster
• Model influence visualization: Thales automatically generates influence diagrams showing the relationships between all species in the model
• Visual trial protocol: users can graphically define simulation pipelines for clinical trial designs