Company Sets New Record for Third Quarter Revenues and Earnings

Simulations Plus Reports Preliminary Results for Third Fiscal Quarter
Company CEO to Present at Wall Street Reporter Small-Cap Discovery Conference

Simulations Plus Releases Combined ADMET Predictor and ADMET Modeler Upgrades
Company's Structure-Property Prediction and Model-Building Software Programs Will Be Sold as a Complete Structure-Property Prediction and Modeling Package

Simulations Plus Receives Multo-Year Pharmaceutical Software License
Large Pharmaceutical Company Renews Multi-year License

Simulations Plus Releases GastroPlus(™) 5.1
Important New Improvements Added to the Company's Gold Standard Software

Simulations Plus Reports Second Quarter FY2006 Financial Results
Company Sets New Record for Second Quarter Revenues and Earnings

Simulations Plus Announces Second Quarter 2006 Earnings Conference Call
Conference Call to be on Thursday, April 13, at 4:15 PM EDT

Simulations Plus Releases ClassPharmer 4.0
Dramatic Improvements in Speed and Function Expected to Improve Drug Discovery

Simulations Plus Renews Important Global Software License
Large Customer Renews Annual Global License for GastoPlus ™

Simulations Plus Announces Conference Call Details
Call To Be Held On Tuesday, December 13, at 4:30 PM EST

Simulations Plus Releases GastroPlus TM Version 5.0
Completion of Two-Year Development Program Adds Major New Functionalities

Simulations Plus Requests Extension for 10K-SB Filing
Company Plans Conference Call Shortly After Release

Simulations Plus Announces Change in Investor Relations
Function to be Moved In-House for Greater Operating Efficiency

Simulations Plus Announces Release of New Toxicity Prediction for ADMET Predictor™
hERG Potassium Channel Blocking Affinity Models Important Cardiac Toxicity

Simulations Plus Expands Field Sales Force
Product Manager to Become Full-time Field Representative

Simulations Plus Acquires Assets of Sage Informatics LLC
New Product Line and Key Employee Expand Software Offerings and Science Staff

Simulations Plus Subsidiary, Words+, Inc., Terminates Royalty and Support Agreement with Sam Communications, LLC
Termination by Mutual Agreement to Result in Reduced Expenses