This webinar with a panel of experienced GastroPlus users aims at providing users, both new and more experienced, with tips and tricks to improve their use of GastroPlus.
PKPlus™ 2.5 Release Webinar
Learn about the latest developments in PKPlus™
GastroPlus® User Group Webinar: Applications/Experiences of PBPK Modeling to Support Regulatory Interactions
Recent experiences with PBPK model-based regulatory submissions used to obtain product development and DDI waivers will be discussed.
Support files in GastroPlus®
This video discusses support files in GastroPlus™.
The GastroPlus® Batch Simulation Mode
This video describes the batch simulation mode in GastroPlus.
The Optimization Module in GastroPlus®
This tutorial discusses the Optimization module in GastroPlus that allows one to optimize simulation model parameters such as initial dose, Vmax, enzyme expression levels, and many others, in order to...
Enzyme and Transporter Expression Levels in GastroPlus® 9.6
This video discusses the enzyme and transporter expression levels that are defined in various tissues, e.g., GI tract, liver, lung, kidney and species (human, dog, monkey, and rat).
The PKPlus Module in GastroPlus® Tutorial
This video shows how to create noncompartment, 1-, 2-, and 3-compartment pharmacokinetic models based on in vivo data using the PKPlus™ module in GastroPlus.
Modeling Enterohepatic Circulation (EHC) in GastroPlus®
This video shows how to set up enterohepatic circulation of ezetimibe in order to accurately simulate the in vivo plasma protein concentration.
Parameter Sensitivity Analysis in GastroPlus®
This video describes how to set up a parameter sensitivity analysis (PSA) in GastroPlus.
Ionization effects in GastroPlus®
This video discusses how the ionization of a molecule effects its dissolution and absorption.
Using Liver Microsomal clearance in GastroPlus®
This video demonstrates how to enter liver microsomal data into GastroPlus with the unit converter and importing the values during structure input.
Adding OATP and MRP-2 transporters to PBPK models in GastroPlus®
This video shows how to add OATP and MRP-2 transporter kinetics to PBPK models.
Converting In Vitro Permeability to Effective Jejunum Permeabililty
This video is a demonstration of Tutorial 5.3.3. It shows how to create a correlation between apparent permeability and effective jejunum permeability.
Tracking Metoprolol Metabolites in GastroPlus® 9.5
This video shows how to track the metabolites of metoprolol in GastroPlus 9.5.
Tracking Metabolites in GastroPlus®
This video shows how to track the N-debutyl metabolite of dronedarone in GastroPlus.
GastroPlus® ADMET Predictor Module
This video shows features available in MedChem Designer™ that are available for users that license the ADMET Predictor™ module within GastroPlus™.
GastroPlus 9 Installation
This video shows how to install GastroPlus and the Flexera licensing system. The installation is the same for various versions.
Application of Cellular Permeability Simulation and PBPK Models to Capture Significance of Transporter Effects on Dose Linearity
In this GastroPlus™ User Group webinar, we will discuss the validation of passive permeability estimates in MembranePlus for a library of diverse compounds and describe the application of MembranePlus to fit intracellular efflux transporter affinity (Km) for GastroPlus™ PBPK models.