The purpose of this study was to compare the dissolution behaviour of etoricoxib in different dissolution media and to establish in vitro/in vivo correlation (IVIVC) using computer simulations.
Simulations Plus Wins Phase II, Small Business Innovation Research Grant
$525,000 Grant to Speed Commercialization of Advancements to Company’s Industry-Leading Molecular Property Prediction Software
Simulations Plus Reports Second Quarter FY2009 Financial Results
Continued Growth – Revenues Up 12.7%, Cash Up 20.2%
Simulations Plus Sets Date for Second Quarter Fiscal Year 2009 Earnings Release and Conference Call
Conference Call to be on Wednesday, April 15, at 4:15 PM EDT
Non-competitive androgen receptor inhibition in vitro and in vivo
Androgen receptor (AR) inhibitors are used to treat multiple human diseases, including hirsutism, benign prostatic hypertrophy, and prostate cancer, but all available...
Kerfuffle!
To become disheveled. A kerfuffle is the polite term for a cascading series of errors that can be initiated by a seemingly innocuous event that then leads to other...
Development of a Steady-State Exposure-Response Model for Exenatide Once Weekly
Exenatide is dosed as a subcutaneous (SC) injection of 5 and 10 μg twice daily (BID) before main meals and is indicated for the treatment of type 2 diabetes mellitus in patients failing to achieve adequate…
Predicting pharmacokinetics of drugs using physiologically based modeling – application to food effects
Our knowledge of the major mechanisms underlying the effect of food on drug absorption allows reliable qualitative prediction based on biopharmaceutical properties...
Modelling and PBPK Simulation in Drug Discovery
Physiologically based pharmacokinetic (PBPK) models are composed of a series of differential equations and have been implemented in a number of commercial...
Calculation of molecular lipophilicity: State-of-the-art and comparison of log P methods on more than 96,000 compounds
We first review the state-of-the-art in development of log P prediction approaches falling in two major categories: substructure-based and property-based methods.
Application of patient population-derived pharmacokinetic-pharmacodynamic relationships to tigecycline breakpoint determination for staphylococci and streptococci
Correctly determined susceptibility breakpoints are important to both the individual patient and to society at large. A previously derived patient population...
Toward an In Vivo Dissolution Methodology: A Comparison of Phosphate and Bicarbonate Buffers
The purpose of this research was to evaluate the difference between the pharmaceutical phosphate buffers and the gastrointestinal bicarbonates in dissolution of ketoprofen and indomethacin...
Simulations Plus Reports First Quarter FY2009 Financial Results
Company Sets New Record for First Quarter: Revenues up 7.5% and Earnings Up Over 28%
Simulations Plus Sets Date for First Quarter Fiscal Year 2008 Earnings Release and Conference Call
Conference Call to be on Thursday, January 15, at 4:15 PM EST
Simulations Plus Releases ClassPharmer™ Version 4.6
New Version Further Improves Powerful Data Mining and Drug Design Capabilities
Justification of biowaiver for carbamazepine, a low soluble high permeable compound, in solid dosage forms based on IVIVC and gastrointestinal simulation
The aim of the present study was to use gastrointestinal simulation technology and in vitro-in vivo correlation (IVIVC) as tools to investigate a possible extension of biowaiver criteria...
Analysis of Risk Factors in Human Bioequivalence Study That Incur Bioinequivalence of Oral Drug Products
In the study of human bioequivalence (BE), newly developed oral products sometimes fail to prove BE with a reference product due to the high variability in pharmacokinetic (PK)...
Busting the Black Box Myth: Designing Out Unwanted ADMET Properties with Machine Learning Approaches
Drug design is usually understood as “an inventive process of finding new medications based on the knowledge of the biological target” – according to the...
Omeprazole: Physiologically Based Pharmacokinetic (PBPK) Modeling and Prediction of Drug-Drug Interactions (DDI)
To optimize a PBPK model of omeprazole for prediction of DDIs with respect to polymorphic expression of CYP enzymes. Omeprazole absorption and pharmacokinetics were simulated using GastroPlus™.