Translational Pharmacokinetics of a Novel Bispecific Antibody Against Ebola Virus (MBS77E) from Animal to Human by PBPK Modeling & Simulation

Translational Pharmacokinetics of a Novel Bispecific Antibody Against Ebola Virus (MBS77E) from Animal to Human by PBPK Modeling & Simulation

Authors: Zhang W, Xiang Y, Wang L, Wang F, Li G, Zhuang X
Publication: Int J Pharm
Keywords: antibodies, biologics, gastroplus, large molecules, monoclonal antibody, NAMVantage, PBPK modeling, physiologically based pharmacokinetics
Software: GastroPlus®
Therapeutic Areas: Biologics

The goal of this study was to construct a PBPK model to accelerate the translation of MBS77E, a humanized bispecific antibody against the Ebola virus.

Investigating the uncertainty of prediction accuracy for the application of physiologically based pharmacokinetic models to animal-free risk assessment of cosmetic ingredients

Investigating the uncertainty of prediction accuracy for the application of physiologically based pharmacokinetic models to animal-free risk assessment of cosmetic ingredients

Authors: Terasaka S, Hayashi A, Nukada Y, Yamane M
Publication: Regul Toxicol Pharmacol
Keywords: admet predictor, cosmetics, gastroplus, IVIVE, mechanistic absorption, ngra, PBPK modeling, physiologically based pharmacokinetics, safety research, toxiokinetics
Software: GastroPlus®

Physiologically based pharmacokinetic (PBPK) models are considered useful tools in animal-free risk assessment.

Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study

Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study

Authors: Van der Veken M, Aertsen M, Brouwers J, Stillhart C, Parrott N, Augustijns P
Publication: Pharmaceutics
Keywords: ACAT, biopharmaceutics, children, gastroplus, gut physiology, mechanistic absorption, pbbm, PBPK modeling, physiologically based pharmacokinetics
Software: GastroPlus®

The volume and distribution of fluids available in the gastrointestinal (GI) tract may substantially affect oral drug absorption.

Utility of Physiologically Based Biopharmaceutics Modeling (PBBM) in Regulatory Perspective: Application to Supersede f2, Enabling Biowaivers & Creation of Dissolution Safe Space

Utility of Physiologically Based Biopharmaceutics Modeling (PBBM) in Regulatory Perspective: Application to Supersede f2, Enabling Biowaivers & Creation of Dissolution Safe Space

Authors: Bhattiprolu AK, Ahmed T, Boddu R, Chachad S
Publication: J Pharm Sci
Keywords: ACAT, bioequivalence, biopharmaceutics, biowaiver, gastroplus, mechanistic absorption, pbbm, PBPK modeling, physiologically based pharmacokinetics, vbe
Software: GastroPlus®
Therapeutic Areas: General/Other

Product DRL is a generic IR tablet formulation with BCS Class-III API, available in two strengths: 50mg & 100mg.

Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment

Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment

Authors: Najjar A, Punt A, Wambaugh J, Paini A, Ellison C, Fragki S, Bianchi E, Zhang F, Westerhout J, Li H, Shi Q, Gant TW, Botham P, Bars R, Piersma A, van Ravenzwaay B, Kramer NI
Publication: Arch Toxicol
Keywords: admet predictor, gastroplus, IVIVE, mechanistic absorption, ngra, PBPK modeling, physiologically based pharmacokinetics, safety research, toxiokinetics
Software: GastroPlus®

With an increasing need to incorporate new approach methodologies (NAMs) in chemical risk assessment and the concomitant need to phase out animal testing, the interpretation of...

A novel transdermal ketoprofen formulation for analgesia in cattle

A novel transdermal ketoprofen formulation for analgesia in cattle

Authors: Mills PC, Owens JG, Reinbold JB, McGowan M, Ellenbergner C, Woldeyohannes S, Satake N
Publication: Journal of Veterinary Pharmacology and Therapeutics
Keywords: analgesia, animals, cattle, in vitro, ketoprofen, MonolixSuite Playlist, pkanalix, rspub, Transdermal delivery
Software: PKanalix®

Ketoprofen is registered in many countries for injectable administration in cattle.

Physiologically based Pharmacokinetic Models under the Prism of the Finite Absorption Time Concept

Physiologically based Pharmacokinetic Models under the Prism of the Finite Absorption Time Concept

Authors: Wu D, Tsekouras AA, Macheras P, Kesisoglou F
Publication: Pharmaceutical Research
Keywords: ACAT, biopharmaceutics, gastroplus, mechanistic absorption, pbbm, PBPK modeling, physiologically based pharmacokinetics
Software: GastroPlus®

To date, mechanistic modeling of oral drug absorption has been achieved via the use of physiologically based pharmacokinetic (PBPK) modeling, and more specifically, physiologically...

Physiologically Based Biopharmaceutics Model for Selumetinib Food Effect Investigation and Capsule Dissolution Safe Space – Part I: Adults

Physiologically Based Biopharmaceutics Model for Selumetinib Food Effect Investigation and Capsule Dissolution Safe Space – Part I: Adults

Authors: Pepin X, Hammarberg M, Mattinson A, Moir AJ
Publication: Pharmaceutical Research
Keywords: PBBM validation, pharmacokinetics, physiological based biopharmaceutics models (PBBM), rspub, Selumetinib
Division: PBPK

A physiologically based biopharmaceutics model (PBBM) was developed to mechanistically investigate the effect of formulation and food on selumetinib pharmacokinetics.

Metabolism of 3-Chlorobiphenyl (PCB 2) in a Human-Relevant Cell Line: Evidence of Dechlorinated Metabolites

Metabolism of 3-Chlorobiphenyl (PCB 2) in a Human-Relevant Cell Line: Evidence of Dechlorinated Metabolites

Authors: Zhang CY, Li X, Flor S, Ruiz P, Kruve A, Ludewig G, Lehmler HJ
Publication: Environ Sci Technol
Keywords: admet predictor, dichlorination, HepG2 cells, MetaDrug, Nt-HRMS, PCB 2 metabolites, untargeted metabolomics
Software: ADMET Predictor®

Lower chlorinated polychlorinated biphenyls (LC-PCBs) and their metabolites make up a class of environmental pollutants implicated in a range of adverse outcomes in...

Simulation of Intraluminal Performance of Lipophilic Weak Bases in Fasted Healthy Adults Using DDDPlusTM

Simulation of Intraluminal Performance of Lipophilic Weak Bases in Fasted Healthy Adults Using DDDPlusTM

Authors: Statelova M, Vertzoni M, Kourentas A
Publication: AAPS J
Keywords: dddplus, Dipyridamole, Gastrointestinal transfer model, Intraluminal drug behavior, ketoconazole, precipitation
Software: ADMET Predictor®

The majority of drug candidates exhibit weakly basic characteristics with high lipophilicity. The risk of intraluminal compound precipitation has been studied in vivo...

Physiologically based pharmacokinetic modeling of daptomycin dose optimization in pediatric patients with renal impairment

Physiologically based pharmacokinetic modeling of daptomycin dose optimization in pediatric patients with renal impairment

Authors: Ye L, You X, Zhou J, Wu C, Ke M, Wu W, Huang P, Lin C
Publication: Front Pharmacol
Keywords: Chinese, disease state, dose optimization, dose selection, gastroplus, PBPK modeling, pediatrics, physiologically based pharmacokinetics, renal impairment
Software: GastroPlus®

Daptomycin is used to treat Gram-positive infections in adults and children and its dosing varies among different age groups.

In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A

In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A

Authors: Becker T, Krome AK, Vahdati S, Schiefer A, Pfarr K, Ehrens A, Aden T, Grosse M, Jansen R, Alt S, Hesterkamp T, Stadler M, Hubner MP, Kehraus S, Konig GM, Hoerauf A, Wagner KG
Publication: Pharmaceutics
Keywords: ACAT, biopharmaceutics, gastroplus, IVIVC, ivivr, mechanistic absorption, pbbm, PBPK modeling, physiologically based pharmacokinetics
Software: GastroPlus®

In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species...

Reliance is key to effective access and oversight of medical products in case of public health emergencies

Reliance is key to effective access and oversight of medical products in case of public health emergencies

Authors: Saint-Raymond A, Valentin M, Nakashima N, Orphanos N, Santos GML, Balkamos G, Azatyan S
Publication: Expert Rev Clin Pharmacol
Keywords: COVID-19, emergency use authorization, international pharmaceutical regulators, vaccines, WHO
Division: PBPK

Responding to new threats and public health emergencies (PHE) creates serious challenges to regulators.

Tissue regeneration effect of betulin via inhibition of ROS/MAPKs/NF-ĸB axis using zebrafish model

Tissue regeneration effect of betulin via inhibition of ROS/MAPKs/NF-ĸB axis using zebrafish model

Authors: Ouyang T, Yin H, Yang J, Liu Y, Ma S
Publication: Biomed Pharmacotherapy
Keywords: Anti-inflammatory effect, Betulin, ROS/MAPKs/NF-ĸB, Tissue regeneration, wound healing, zebrafish
Software: ADMET Predictor®
Therapeutic Areas: Inflammation

Betulin is the primary anti-inflammatory component of Betula platyphylla suk. cortex (birch bark), a time-honored Traditional Chinese Medicine (TCM) for healing trauma...

Nanoclay-Based Composite Films for Transdermal Drug Delivery: Development, Characterization, and in silico Modeling and Simulation

Nanoclay-Based Composite Films for Transdermal Drug Delivery: Development, Characterization, and in silico Modeling and Simulation

Authors: Sikandar M, Shoaib MH, Yousuf RI, Ahmed FR, Ali FR, Saleem MT, Ahmed K, Sarfaraz S, Jabeen S, Siddiqui F, Husain T, Qazi F, Imtiaz MS
Publication: Int J Nanomedicine
Keywords: biopharmaceutics, dermal absorption, gastroplus, IVPT, pbbm, PBPK modeling, physiologically based pharmacokinetics, Skin permeation, tcat
Software: GastroPlus®

Purpose: Halloysite nanotubes (HNTs) are a versatile and highly investigated clay mineral due to their natural availability, low cost, strong mechanical strength, biocompatibility, and binding properties.

Case study on the impact of the source of metabolism parameters in next generation physiologically based pharmacokinetic models: Implications for occupational exposures to trimethylbenzenes

Case study on the impact of the source of metabolism parameters in next generation physiologically based pharmacokinetic models: Implications for occupational exposures to trimethylbenzenes

Authors: Sweeney LM
Publication: Regul Toxicol Pharmacol
Keywords: PBPK, TMB isomers, toxicokinetics
Software: ADMET Predictor®

Physiologically based pharmacokinetic (PBPK) models are a means of making important linkages between exposure assessment and in vitro toxicity. A key constraint on rapid...

Recent trends in pharmaceutical analysis to foster modern drug discovery by comparative in-silico profiling of drugs and related substances

Recent trends in pharmaceutical analysis to foster modern drug discovery by comparative in-silico profiling of drugs and related substances

Authors: Ganorkar SB, VanderHeyden Y
Publication: TrAC Trends Anal Chem
Keywords: ADMET, Bioactivity, drug discovery, Drug impurities, In-Silico toxicity testing, molecular modeling, Pharmaceutical drug analysis, Related substances
Software: ADMET Predictor®

Pharmaceutical drug analysis (PDA), besides quantifying drugs and related substances (RS), can enrich drug discovery (DD) by suggesting new leads. PDA may...