Simulations Plus

Record revenues achieved in both business units

Conference Call to be on Tuesday, July 15, at 4:15 PM EDT

ADMET Predictor™ 3.0 Employs New Technology for Molecular Descriptors, All New Predictive Models

Agency Licenses Both Toxicity and New Enslein Metabolism Modules

ClassPharmer™ 4.5 Adds Powerful New Capabilities for Drug Molecule Design and Data Mining

Pfizer Study Presented at International Society for the Study of Xenobiotics (ISSX) Meeting in Shanghai

Version 6.0 Incorporates Major Upgrades to Several Modules, Additional User Conveniences

Company Adds Parsippany, NJ Site to Multi-year Agreement

Revenues Up 4.3%, and Earnings Up 9.0% for First 6 Months of FY2008

Conference Call to Be on Tuesday, April 15, at 4:15 PM EDT

Adds New ADMET Predictor(TM) Module

Top 3 Company Adds Software Licenses to Multi-year Agreement

Version 2.4 Adds Industry’s First Metabolism Kinetics Module for Key Enzymes

Revenues Increase 36%, Earnings Increase 232%

Version 5.3 Further Enhances Industry's Gold Standard Product

Dr. John Crison Joins Simulations Plus

Prediction of Metabolism from Important Group of Enzymes to be Added to ADMET Predictor™