CEO to be Interviewed by the Wall Street Reporter
Simulations Plus Announces Stock Dividend
Board of Directors Approves Two-for-One Stock Split
Simulations Plus Reports Third Quarter FY2006 Financial Results
Company Sets New Record for Third Quarter Revenues and Earnings
Inhibition of the NF-kappaB pathway by varicella-zoster virus in vitro and in human epidermal cells in vivo
Varicella-zoster virus (VZV) is an alphaherpesvirus that causes varicella and herpes zoster. Using human cellular DNA microarrays, we found that many nuclear factor kappa B...
In silico prediction of aqueous solubility
The fundamentals of aqueous solubility, and the factors that affect it, are briefly outlined, followed by a short introduction to quantitative structure-property relationships.
Simulations Plus Reports Preliminary Results for Third Fiscal Quarter
Company CEO to Present at Wall Street Reporter Small-Cap Discovery Conference
Simulations Plus Releases Combined ADMET Predictor and ADMET Modeler Upgrades
Company's Structure-Property Prediction and Model-Building Software Programs Will Be Sold as a Complete Structure-Property Prediction and Modeling Package
Simulations Plus Receives Multo-Year Pharmaceutical Software License
Large Pharmaceutical Company Renews Multi-year License
Simulations Plus Releases GastroPlus(™) 5.1
Important New Improvements Added to the Company's Gold Standard Software
Simulations Plus Reports Second Quarter FY2006 Financial Results
Company Sets New Record for Second Quarter Revenues and Earnings
Simulations Plus Announces Second Quarter 2006 Earnings Conference Call
Conference Call to be on Thursday, April 13, at 4:15 PM EDT
Pharmacokinetic/Pharmacodynamic (PK/PD) Model for the Safety of Tigecycline (T) in Patients with Complicated Intra-Abdominal Infections (cIAI)
Nausea (N) and vomiting (V) have been reported with tigecycline, a new glycylcycline with expanded broad spectrum activity. 140 exposure-response relationships and patient covariates predictive of the first N…
NIPALSTREE: A New Hierarchical Clustering Approach for Large Compound Libraries and Its Application to Virtual Screening
A hierarchical clustering algorithm NIPALSTREE was developed that is able to analyze large data sets in high-dimensional space. The result can be displayed as a dendrogram.
Simulations Plus Releases ClassPharmer 4.0
Dramatic Improvements in Speed and Function Expected to Improve Drug Discovery
Mutational analysis of the varicella-zoster virus ORF62/63 intergenic region
The varicella-zoster virus (VZV) ORF62/63 intergenic region was cloned between the Renilla and firefly luciferase genes, which acted as reporters of ORF62 and ORF63...
Pharmacokinetic/pharmacodynamic (PK/PD) Model for Tolvaptan in Healthy Subjects
Direct effect, indirect effect, and competitive antagonism models were evaluated to describe plasma tolvaptan concentration effect on urine flow rate (UFR), with consideration of water intake rate (WIR)…
Pharmacokinetic-pharmacodynamic relationships describing the efficacy of oritavancin in patients with Staphylococcus aureus bacteremia
Bloodstream infections due to antimicrobial-resistant Staphylococcus aureus occur with increasing frequency and represent an important cause of morbidity and mortality.
Are Target-Family-Privileged Substructures Truly Privileged?
One of the early and effective approaches to G-coupled protein receptor target family library design was the analysis of a set of ligands for frequently occurring chemical moieties or substructures.
Assessing the Scaffold Diversity of Screening Libraries
Medicinal chemists have traditionally realized assessments of chemical diversity and subsequent compound acquisition, although a recent study suggests that experts are usually inconsistent in reviewing large data sets.