Zalcitabine population pharmacokinetics: application of radioimmunoassay

Zalcitabine population pharmacokinetics: application of radioimmunoassay

Publication: Antimicrob Agents Chemother

Zalcitabine population pharmacokinetics were evaluated in 44 human immunodeficiency virus-infected patients (39 males and 5 females) in our immunodeficiency clinic.

Dose proportionality of cisatracurium

Dose proportionality of cisatracurium

Publication: Pharm Res

The dose proportionality of cisatracurium pharmacokinetics was assessed using a population approach by incorporating the collection of sparse...

Pretreatment regimens for adverse events related to infusion of amphotericin B

Pretreatment regimens for adverse events related to infusion of amphotericin B

Publication: Clin Infect Dis

Infusion-related adverse events (IRAEs) such as nausea, vomiting, fever, chills, and thrombophlebitis that are associated with amphotericin B therapy often lead clinicians to prescribe a number of adjunctive pretreatment medications...

Sepsis syndrome and associated sequelae in patients at high risk for gram negative sepsis

Sepsis syndrome and associated sequelae in patients at high risk for gram negative sepsis

Publication: Pharmacotherapy

We conducted a prospective surveillance study of 80 hospitals across the United States to determine the incidence of sepsis syndrome and its associated sequelae in hospitalized patients over age 18 years who...

Effects on recovery when isoflurane is used to supplement propofol-nitrous oxide anesthesia

Effects on recovery when isoflurane is used to supplement propofol-nitrous oxide anesthesia

Publication: Anesth Analg

During propofol-nitrous oxide (N2O) anesthesia, volatile anesthetics are frequently administered to treat signs of inadequate anesthesia and to decrease the possibility of intraoperative awareness.

Hemodynamic effects of propofol: data from over 25,000 patients

Hemodynamic effects of propofol: data from over 25,000 patients

Publication: Anesth Analg

To investigate clinically important hypotension and bradycardia after induction of anesthesia with propofol, we analyzed data from a Phase IV stepwise study involving 25,981 patients, 1722 institutions, and 1819 anesthesiologists. In Step 1, propofol was used for...

Phase IV study of propofol: validation of the data set

Phase IV study of propofol: validation of the data set

Publication: Anesth Analg

In 1989-1990, Stuart Pharmaceuticals conducted a Phase IV study of propofol on over 26,000 patients, later making the large data base available to a team of epidemiologists and anesthesiologists for analysis.

How do anesthesiologists select patients when introducing a new drug into practice

How do anesthesiologists select patients when introducing a new drug into practice

Publication: Anesth Analg

As part of the marketing strategy for the anesthetic drug propofol (Diprivan), Stuart Pharmaceuticals began a Phase IV postmarketing study soon after the drug received Food and Drug Administration approval in 1989.