NAFLDsym Application Showcase: Key Examples of NAFLDsym Use within Drug Development

NAFLDsym Application Showcase: Key Examples of NAFLDsym Use within Drug Development

Software: NAFLDsym®

NAFLDsym is a quantitative systems pharmacology (QSP) modeling software to support the development of treatments for non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).

Human-on-a-Chip combined with PBPK modeling for in vitro/in vivo PK/PD extrapolation

Human-on-a-Chip combined with PBPK modeling for in vitro/in vivo PK/PD extrapolation

Authors: Hickman J, Lukacova V
Software: GastroPlus®
Division: PBPK

Human-on-a-Chip (HoaC) systems are becoming valuable tools to study, understand disease physiology, and expand the prediction of pharmacodynamic effects before first-in-human studies. They can also be used to evaluate the toxic effects of compounds in non-pharma industries where these effects cannot be examined in vivo.