Typically, at the beginning of a project, the scope is defined along with the timelines and budget. As project team leaders negotiate with functional managers to recruit key team members, including…
Lean Production
I have been reading The Machine That Changed the World: The Story of Lean Production (1), by James Womack and others from MIT’s International Motor Vehicle Program (Content no longer available) research team. This book caused a sensation 20 years ago with its description of the Toyota Production System. The blurb on the book’s back cover says, “The hallmarks of lean production are teamwork, communication, and efficient use of resources. The results are remarkable cars with one-third the defects, built in half the factory space, using half the man-hours.”
Semi-mechanistic PK/PD Model of the Effect of Odanacatib, a Cathepsin K Inhibitor, on Bone Turnover to Characterize Lumbar Spine Bone Mineral Density in Two Phase II Studies of Postmenopausal Women
Odanacatib (MK-0822), a potent, orally-active inhibitor of cathepsin K, is under clinical development for treatment of postmenopausal osteoporosis. This poster describes base model development of a...
Simulations Plus Launches Biorelevant Solubility Database
Proprietary Data Generated by Company Provides Unique Insight Needed By Drug Developers
Simulations Plus Announces Renewed Share Repurchase Program
Up to One Million Shares over 12 Months Authorized by Board of Directors
Intro to Pharma of the Future?
Why is it so hard to incorporate modeling and simulation into drug development? Why do these powerful tools so often fail to provide satisfactory outcomes?
Simulations Plus Reports First Quarter FY2010 Financial Results
Record First Quarter Sees Pharmaceutical Software and Services Revenues Jump 21%, Consolidated Earnings Up 38% from 1QFY09
Paul Volcker: Think More Boldly
In December 2009, The Wall Street Journal sponsored its second Future of Finance Initiative (links to a dead page) to provide a forum for 80 of the world’s top financiers to brainstorm suggestions for reforming the financial system in the wake of the 2008 implosion of the global economy.
Development of a Physiologically Based Pharmacokinetic (PBPK) Model for Predicting Deposition and Disposition follo · g Inhaled and Intranasal Administration
The selection of a biologically active molecule as a successful inhaled therapeutic agent depends on its pharmacokinetic and safety properties...
Simulations Plus Appoints John DiBella, M.S., Manager, Marketing and Sales
New Leadership Brings Strength in Science and Engineering
Simulations Plus Appoints Robert D. Clark, PH. D., Director of Life Sciences
Dr. Clark to Join Team in January
Simulations Plus Launches Abbreviate!™ for the iPhone™
New Software Speeds Up Typing on the PopularApple® iPhoneTM and iPod Touch®
Modeling Drug Disposition of Timolol in Ocular Tissues of Rabbit following Topical Eye Drops
Recently, we reported the successful application of a novel mathematical model describing drug disposition in eye compartments to simulate disposition of clonidine after topical (eye drop) administration.
David Foster Wallace
I have become addicted to David Foster Wallace’s nonfiction essays, several of which were published in A Supposedly Fun Thing I’ll Never Do Again.*
Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data
The aim of this study was to evaluate a strategy based on a physiologically based pharmacokinetic (PBPK) model for the prediction of PK profiles in human using in vitro...
Simulations Plus Reports FY2009 Financial Results
Sales up 2% to $9.143 Million, Cash up 26.9%, Earnings $0.08 Per Fully Diluted Share
Simulations Plus Sets Date for Fiscal Year 2009 Earnings Release and Conference Call
Conference Call to Be on Monday, November 30, at 4:15 PM EST