Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling

Authors: Li GF, Wang K, Chen R, Zhao HR, Yang J, Zheng QS
Publication: Acta Pharmacol Sin
Keywords: Advanced Compartmental Absorption Transit (ACAT) model, bisoprolol, intravenous, oral, oral administration, pharmacokinetics
Software: GastroPlus®

Aim

To develop and evaluate a whole-body physiologically based pharmacokinetic (WB-PBPK) model of bisoprolol and to simulate its exposure and disposition in healthy adults and patients with renal function impairment.