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Nov 24, 2012

Toxicological considerations of acetylcholinesterase reactivators

Introduction

The more or less systematic studies on the specific activity of oximes as reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus (OP) compounds provide a panoramic image of their pharmacological and toxicological profiles. Established structure–activity relationships are still unable to adequately predict their antidotal efficacy. However, the in vivo behavior of oximes is a direct consequence of their physico-chemical properties, considerably limiting the passive transport across the biological barriers.

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