In drug development, uncertainty is inevitable—but costly surprises don’t have to be.

We help teams like yours replace trial-and-error with foresight. Our AI-assisted modeling and simulation platforms integrate mechanistic science, data-driven intelligence, and scalable cloud compute to predict efficacy, safety, dosing, and clinical performance earlier in development. The result is faster learning, smarter investment, and a clearer return on R&D spend – and supporting a new approach methodology (NAM) future.

A laptop shows a colorful DILI molecular simulation using GastroPlus and ADMET Predictor software.
Integrated Modeling Across the Drug Lifecycle
  • PBPK & PBBM

    GastroPlus®, MembranePlus™, and DDDPlus™ work together to assess formulation strategies, anticipate drug–drug interactions, predict absorption and exposure, inform dose selection, support biowaivers, and reduce reliance on animal studies—turning data into confident development decisions.

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  • QSP & QST

    Our validated quantitative systems pharmacology and toxicology platforms and licensable library models deliver systems-level insight across therapeutic and safety domains, from metabolic and inflammatory diseases to oncology and organ safety. These customizable tools help teams understand why outcomes occur and explore scenarios before committing time and capital.

    See our QSP/QST models

  • Pharmacometrics

    MonolixSuite™, which includes PKanalix®, Monolix®, and Simulx®, supports the full pharmacometrics workflow—from data exploration and population modeling to clinical trial simulation—within a single, coherent environment designed for speed, rigor, and regulatory confidence.

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Designed for the Future of R&D

Our platforms work together—AI-enabled, cloud-ready, and integrated across discovery, development, and clinical decision-making.
This connected approach allows teams of any size to move faster, reduce risk, and focus resources on the programs most likely to succeed.

See What Predictive
R&D Looks Like

Discover how Simulations Plus software helps transform data into insight,
insight into decisions, and decisions into measurable value—clearly, confidently,
and at scale.

Schedule a Demo
A modern office desk with multiple screens shows Simulations Plus ADMET Predictor and modeling tools in use.