01. PROMO
DDDPlus™
04. DDDPlus™ WHAT & HOW
Novel Approaches

We have always been dedicated to carefully implement the best theories and develop novel approaches within the DDDPlus dissolution models. You enter limited physicochemical & manufacturing data, set up your dissolution method, and DDDPlus provides the rest:

  • Simple, intuitive user interface
  • Model optimization
  • High-quality plots & figures for reporting purposes
  • Excellent customer support
  • Integration with our other tools, like ADMET Predictor® (QSAR) and GastroPlus® (PBPK & PBBM)
  • The in vitro processes which are considered in the DDDPlus simulations, and the methods we’ve introduced to parameterize them, are too numerous to list here – instead, take a peek at the DDDPlus brochure for more details.

The DDDPlus dissolution modeling platform has been utilized by companies across various industries and departments since 2006. Some of the routine applications include:

  • Assessing formulation strategies to achieve target dissolution profiles
  • Assisting with dissolution method development
  • Applying virtual ‘lot-to-lot’ variability effects to help establish dissolution specifications – remove the guesswork associated with the identification of dissolution variability and its impact on PK exposure
  • Facilitating Quality by Design (QbD) implementation to guide product development
  • Integrating with GastroPlus absorption, PBPK and PBBM models to optimize formulations and generate mechanistic in vitro-in vivo correlations (IVIVCs) – better extrapolation of dissolution inputs for PBPK & PBBM modeling… and more!

How do you spell relief?

Version 6 will continue providing the industry’s leading software for the in vitro dissolution experiment of pharmaceutical dosage forms! Model powders, capsules, both swellable and non-swellable and non-swellable polymer matrices, coated beads, delayed release, single or bilayer tablets and NEW controlled release and long acting injectable, dosage types.

NEW in DDDPlus version 6:

  • New mechanistic Artificial Stomach-Duodenum model
  • New in vitro dissolution apparatus models for improved IVIVE of precipitation kinetics with GastroPlus®:
    • Biphasic dissolution
    • Membrane dissolution
  • New controlled release and Long Acting Injectable dosage form models
  • and more!

Save time & money on your formulation design – request a software evaluation here.

05. EVENTS
Upcoming Events
06. DDDPlus™ Publications
Peer-reviewed Publications