Your modeling tool for IVIVE of absorption and systemic clearance/distribution processes…
For over 20 years, significant research has been devoted to in vitro permeability (e.g., Caco-2 assays) and hepatocyte systems, with several guidelines being published and all pharmacopeia describing appropriate methods for testing.
Unfortunately, these experiments are expensive, and since you don’t have a lot of time or material available, how do you prioritize which compounds to test early in your project? Once you have identified a few promising leads, is your experimental design robust enough to capture all of the relevant information you need? And, after you collect the data and compile your apparent permeability or intrinsic clearance, are you certain you are not overlooking anything?
Enter MembranePlus™, the industry’s leading mechanistic in vitro permeability & hepatocyte modeling software. MembranePlus is helpful for:
Users of GastroPlus® looking to better inform inputs (e.g., lysosomal trapping, diffusional clearances, biliary excretion) for more accurate in vivo absorption and systemic clearance/distribution predictions with the Advanced Compartmental Absorption and Transit (ACAT™) and PBPK models
Discovery scientists looking to categorize compounds into high and low permeability classes
DMPK researchers that focus on in vitro transporter/metabolism kinetic studies – model your measured data to capture all relevant information from the expensive experiments you are running
Enter MembranePlus™, the industry’s leading mechanistic in vitro permeability & hepatocyte modeling software.
The Transdermal Compartmental Absorption and Transit Module in MembranePlus
Passive Transport Model Improvements
The MembranePlus permeability modeling platform has been utilized by companies across various industries and departments since 2014. MembranePlus has several primary applications:
Simulation of in vitro permeability & hepatocyte concentrations
Analysis of measured in vitro experimental data
The program provides several simulation modes to help you achieve your goals:
Single simulation – based on your drug properties (whether measured or predicted through ADMET Predictor) and permeability or hepatocyte experimental setup, easily run a simulation to predict the time course changes in concentrations (e.g., apical, basolateral, cellular or lysosomal).
Parameter sensitivity analysis (PSA) – during early drug development, researchers have a large number of compounds to evaluate and limited resources. With Parameter Sensitivity Analysis, quickly assess the impact of changes to certain properties (e.g., physicochemical or experimental) on critical endpoints. This can help guide your resource allocation plans and identify which permeability or hepatocyte experiments should be done next.
Batch mode – quickly screen a library of compounds based on predicted permeability or run the same compound through a series of different Caco-2, PAMPA, MDCK, or hepatocyte experiments. Easily prioritize compounds in any way you like: from high to low permeability, based upon potential issues with lysosomal trapping, etc.
Check out various case studies using MembranePlus and GastroPlus® by reviewing publications and webinars on our Resource Center.
Check out the exciting new features in MembranePlus v3! This version takes modeling of in vitro systems to the next level, allowing you to capture all relevant information from your experiments.
View the full MembranePlus v3 release notes.
MembranePlus v3 is now available for download – instructions can be found here!
James Mullin
Haiying Zhou
