Proportional hazard models are a popular class of models for time-to-event data.
Case study: Inter-occasion variability and effect of guar gum on alcohol concentration in blood
In this case study, the MonolixSuite is used to analyze and model the PK of alcohol, measured in two different occasions where subjects...
Feature of the week #86: Estimating the conditional distributions
The task Conditional distribution in Monolix estimates the individual conditional distributions, which represent the individual...
GastroPlus® “Workshop from Home” April 17 PBPK PD modeling course with Haiying Zhou
Advanced GastroPlus® DMPK & Clinical Pharmacology
GastroPlus® “Workshop from Home” April 16 Transporters in PBPK modeling with Ke Szeto
Advanced GastroPlus® DMPK & Clinical Pharmacology
GastroPlus® “Workshop from Home” April 15 DDI predictions with John DiBella
Advanced GastroPlus® DMPK & Clinical Pharmacology
GastroPlus® “Workshop from Home” April 14 Special population predictions with Viera Lukacova
Advanced GastroPlus® DMPK & Clinical Pharmacology
GastroPlus® “Workshop from Home” April 13 GastroPlus® Introduction with Maxime Le Merdy
Introductory GastroPlus® Simulation and Modeling
Feature of the week #85: Modeling exposure-response curves
Exposure-response curves give the response to a drug as a function of exposure, which can be the dose or a measure of drug...
Early assessment of PK properties with the ADMET Predictor® HTPK Simulation module, a high-throughput mechanistic PBPK approach
This webinar introduces how the ADMET Predictor® HTPK Simulation module can effectively be used to provide early PK assessment in discovery programs.
Live Stream Learning with Simulations Plus: Day One
Bringing you scientific talks & poster presentations you missed from the 59th Annual SOT/Tox Expo and American Society for Clinical Pharmacology & Therapeutics conference by Simulations Plus… virtually.
Clinical DILI and State-of-the-Art Solutions
Translating in vitro safety data into quantitative risk assessment in specific patient populations remains a challenge.
Feature of the week #84: VPC for time-to-event data
VPC of survival data is a crucial diagnostic plot in the modeling of time-to-event data
Feature of the week #83: Several ways to handle the baseline of PD models
The baseline of PD models can be estimated as a model parameter, fixed to the observed value or a mixture of both.
Feature of the week #82: Kaplan-Meier estimator
Have you ever wondered how the survival function is estimated from time-to-event data?
Feature of the week #81: Efficient alternative implementation for common equations including delays
Delayed differential equations (DDEs) can be implemented in Mlxtran language using the "delay" function.
GastroPlus® Tutorial: Getting Started with GastroPlus – A Software Introduction
Maxime LeMerdy introduces GastroPlus 9.7 interface and walks you through each tab.
Feature of the week #80: Understanding and using the Monolix ‘proposal’
Monolix is able to use the individual parameters of the current run to pre-test several covariate, correlation and error models
Prediction of pH-Dependent Drug-Drug Interactions for Basic Drugs using PBBM Modeling: Industry Case Studies
Acid-reducing agents (ARA) such as antacids, histamine H2-receptor antagonists, and proton pump inhibitors are widely prescribed in several disease states.
Feature of the week #79: Understanding and using the statistical tests in Monolix
The statistical tests complement the diagnostic plots to guide the user in the development of the statistical model.