Prediction of drug-drug interaction (DDI) between cilostazol and substrates or inhibitors of CYP 2C19 and 3A4

Authors: Lukacova V, Chung J, Fraczkiewicz G, Woltosz WS, Bolger MB
Keywords: ACAT model, CYP, drug-drug interactions (DDIs), metabolic clearance, pharmacokinetics (PK)
Software: GastroPlus®
Division: Simulations Plus

Aim

The aim of this study was to validate the utility of physiologically based pharamcokinetic (PBPK) models fore predictioin of DDI between cilostazol, kectoconazole, omeprazole and quindine.

By Viera Lukacova, Grace Fraczkiewicz, Walt Wolotosz, Micahel B Bolger