NAFLDsym v2B is a computational model of MASLD and can be used to predict efficacy for treatment modalities developed for treating MASLD and MASH. NAFLDsym v2B includes many of the primary components of MASLD and MASH pathophysiology such as:

  • Steatosis
  • Regulation of liver triglyceride and fatty acids
  • Lipotoxicity
  • Fibrosis
  • Inflammation
  • Liver injury and proliferation
  • Hepatocellular bioenergetics
  • Dynamic body weight and its effects on lipids
  • Biomarkers (e.g., ALT, AST, cytokeratin cleaved K18, NAS, MRI, MRE, fibrosis score)

NAFLDsym® is computer software, namely, downloadable computer software for conducting simulations of compounds such as drugs or chemicals to evaluate and model their effects on liver disease, namely, non-alcoholic steatohepatitis or non-alcoholic fatty liver disease.

Request a license for or evaluation of NAFLDsym®