Computational Simulation of Complex Dermal Topical Formulations

Conference: SLP MIDD+
Software: GastroPlus®
Division: Simulations Plus


By integrating systems of rate equations, the Transdermal Compartmental Absorption & Transit (TCAT) Model in GastroPlus® (Simulations Plus, Inc) simulates the dynamics of topical and transdermal dosage forms and the dermato-PK of compounds delivered from them. As part of an effort to expand the model’s capabilities, we have developed case studies for several small molecules in gel and micro-emulsion formulations. Here, we describe our work on the steroid, clobetasol-17 propionate (CP).

By William van Osdol, Jin Dong & Jessica R Spires

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Presented at SLP MIDD+ Virtual Conference March 3-4, 2021