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Jul 1, 2022
  |  Video

First in Human (FIH) PBPK predictions

Introduction

An overview of what PBPK is will be provided so that everyone starts from the same level. How PBPK is used will be discussed with a particular focus on FIH PK predictions. Key components of a FIH PK prediction for oral administration will be reviewed: absorption, distribution, metabolism and elimination, plus uncertainty analysis. We will finish with case studies highlighting where PBPK was used to avoid a clinical study and how human efficacious doses can be predicted.

By Neil Miller

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