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This Month In GastroPlus™ Modeling

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Visual variability check for population simulations

Do you modify liver blood flow values in GastroPlus PBPK models?

What are your preferred values for the Percent Fluid in SI & Colon in the ACAT model?

Effective GI permeability for pre-clinical species?

*note: must sign into LinkedIn and be a member of the GastroPlus User Group to review and contribute

New peer-reviewed journal publications citing various applications of GastroPlus software.

Phase I study of the investigational oral mTORC1/2 inhibitor sapanisertib (TAK-228): tolerability and food effects of a milled formulation in patients with advanced solid tumours.

A framework for 2-stage global sensitivity analysis of GastroPlus™ compartmental models.

Monitoring of erlotinib in pancreatic cancer patients during long-time administration and comparison to a physiologically based pharmacokinetic model.

An in vitro – in silico approach for the formulation and characterization of ranitidine gastroretentive delivery systems.

Physiologically-Based Pharmacokinetic Modeling in Lead Optimization I: Evaluation and Adaptation of GastroPlus to Predict Bioavailability of Medchem Series.

Physiologically-Based Pharmacokinetic Modeling in Lead Optimization II: “Rational Bioavailability Design” by Global Sensitivity Analysis to Identify Properties Affecting Bioavailability.