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This Month In GastroPlus™ Modeling

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How well does GP predict brain PK in mice and more specifically in mdr1 -/- mice? Can rate of entry be predicted?

LogP

Food Effect Projections via Physiologically Based Pharmacokinetic Modeling: Predictive Case Studies

IVIVC level C

Question on simulation of re-dissolution of precipitated drug particles in GI tract

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New peer-reviewed journal publications citing various applications of GastroPlus software.Physiologically Based Absorption Modeling to Predict Bioequivalence of Controlled Release and Immediate Release Oral Products.

Application of a Dynamic Fluid & pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus™.

Integration of Precipitation Kinetics From an In vitro, Multicompartment Transfer System and Mechanistic Oral Absorption Modeling for Pharmacokinetic Prediction of Weakly Basic Drugs.

Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERα covalent antagonist (SERCA).

Prediction of ARA/PPI Drug-Drug Interactions at the Drug Discovery and Development Interface.