DDDPlus™

Simulation software for the in vitro dissolution experiment of pharmaceutical dosage forms

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Reimagine the in vitro dissolution experiment…

Today, dissolution studies are the most frequently used tools in the development, characterization, and utilization process of pharmaceutical dosage forms, both immediate and controlled-release. As a formulation or CMC scientist, you’re often tasked with designing a product which achieves a target in vitro dissolution rate that will, hopefully, lead to desired in vivo exposure levels. Or, the lifecycle management team wants to assess the possibility of creating a once-a-day formulation which is bioequivalent to a B.I.D. (twice a day) or T.I.D. (three times a day) dosing regimen. You don’t have a lot of time or material available, so you begin manufacturing small lots of products to test under different conditions, hoping something works. What if there was a more efficient strategy?

Welcome to DDDPlus™, the industry’s leading mechanistic in vitro dissolution software for formulation and analytical scientists. With DDDPlus, you can model and simulate the in vitro dissolution of active pharmaceutical ingredients (API) and formulation excipients under various experimental conditions in seconds, and begin making informed decisions to help improve your chances for success.

What are we providing with DDDPlus?

We have always been dedicated to carefully implement the best theories and develop novel approaches within the DDDPlus dissolution models. You enter limited physicochemical & manufacturing data, set up your dissolution method, and DDDPlus provides the rest:

  • Simple, intuitive user interface
  • Model optimization
  • High-quality plots & figures for reporting purposes
  • Excellent customer support
  • Integration with our other tools, like ADMET Predictor™ and GastroPlus™
  • The in vitro processes which are considered in the DDDPlus simulations, and the methods we’ve introduced to parameterize them, are too numerous to list here – instead, take a peek at the DDDPlus datasheet for more details.

 

How is DDDPlus being applied?

The DDDPlus dissolution modeling platform has been utilized by companies across various industries and departments since 2006. Some of the routine applications include:

  • Assessing formulation strategies to achieve target dissolution profiles
  • Assisting with dissolution method development
  • Applying virtual ‘lot-to-lot’ variability effects to help establish dissolution specifications – remove the guesswork associated with the identification of dissolution variability and its impact on PK exposure
  • Facilitating Quality by Design (QbD) implementation to guide product development
  • Integrating with GastroPlus™ absorption/PBPK models to optimize formulations and generate mechanistic in vitro-in vivo correlations (IVIVCs) – better extrapolation of dissolution inputs for PBPK modeling
  • … and more!

How do I move forward from here?

Join your peers around the world and begin working with DDDPlus to design better pharmaceutical products and experiments.

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