Determining appropriate dosage for your first in human (FIH) clinical trials is critical.
Biopharmaceuticals are increasingly used to treat various medical conditions, but BILI events can end...
Patients with non-alcoholic steatohepatitis (NASH) do not currently have options for pharmaceutical...
Collect input data for dissolution modeling and test multiple conditions
GastroPlus® Newsletter November 2023
Systemic sclerosis (SSc) is a rare connective tissue and autoimmune disease associated with inflammation of the skin and internal organs. Interstitial lung disease (ILD), a frequent complication of SSc with highly variable course, is associated with increased morbidity and mortality risk¹. Two FDA-approved treatments, anti-inflammatory tocilizumab (TCZ) and anti-fibrotic nintedanib (NIN)...
NAFLDsym® is a quantitative systems pharmacology (QSP) platform that simulates progression and treatment of nonalcoholic fatty liver...
Multiprotic ionization is often poorly understood in the pharmaceutical industry.
Novel Acute kidney injury (AKI) biomarkers enhance disease understanding and aid...
PKanalix® is a user-friendly and fast application for compartmental analysis (CA), non-compartmental analysis (NCA) and bioequivalence studies (BE)
Oral suspensions are heterogeneous disperse systems, and the particle size distribution, crystalline form of the dispersed solid, and composition of the formulation can be listed as parameters that control the drug dissolution rate and its bioavailability.
COSSAC Conditional Sampling use for Stepwise Approach based on Correlation tests
SAMBA Stochastic Approximation for Model Building Algorithm
Amparo de la Peña, Vice President of Pharmacometrics at Simulations Plus, will join Jeff Sachs, Pavan Vaddady and Hao Zhu as new board members for 2024.
World‘s best in class pKa prediction tool
pKa important factor in research screening cascade of molecules
Are your clinical trials showing potential liver toxicity?
Glaucoma, caused by an elevation of the intra-ocular pressure (IOP), leads to vision loss
There are many different things that make a model "good."
GastroPlus is a mechanistically based simulation software backage that simulates intravenous, oral, oral cavity, ocular, inhalation, dermal, subcutaneous, and intramuscular absorption...