Determining appropriate dosage for your first in human (FIH) clinical trials is critical.
Quantitative Systems Toxicology (QST) Modeling Using a New Virtual Population in BIOLOGXsym Offers Mechanistic Insights Into Bile Acid-mediated Biologics-induced Liver Injury (BILI) Upon Cimaglermin Alfa (GGF2) Administration
Biopharmaceuticals are increasingly used to treat various medical conditions, but BILI events can end...
Advancing the Multi-Targeted Mechanisms of Action of a Mitochondrial Activator (AXA1125) for Treating NASH Using a Quantitative Systems Pharmacology Model
Patients with non-alcoholic steatohepatitis (NASH) do not currently have options for pharmaceutical...
Mechanistic dissolution data modeling for PBBM introduction: The P-PSD approach
Collect input data for dissolution modeling and test multiple conditions
November 2023 GastroPlus Newsletter
GastroPlus® Newsletter November 2023
ILDSYM®, A Quantitative Systems Pharmacology (QSP) Platform, Successfully Simulates Efficacy of Key Treatments for Systemic Sclerosis-Interstitial Lung Disease
Systemic sclerosis (SSc) is a rare connective tissue and autoimmune disease associated with inflammation of the skin and internal organs. Interstitial lung disease (ILD), a frequent complication of SSc with highly variable course, is associated with increased morbidity and mortality risk¹. Two FDA-approved treatments, anti-inflammatory tocilizumab (TCZ) and anti-fibrotic nintedanib (NIN)...
Accelerating a QSP Model of Nonalcoholic Steatohepatitis (NASH) Using the Julia Language
NAFLDsym® is a quantitative systems pharmacology (QSP) platform that simulates progression and treatment of nonalcoholic fatty liver...
Ionization Prediction Summit Webinar Series: Session 4 Experimental Aspects of pKa Measurements
Multiprotic ionization is often poorly understood in the pharmaceutical industry.
Mechanistic Representation of NAG Release in Relation to Renal Proximal Tubular Cellular Injury
Novel Acute kidney injury (AKI) biomarkers enhance disease understanding and aid...
PKanalix Platform Comparision
PKanalix® is a user-friendly and fast application for compartmental analysis (CA), non-compartmental analysis (NCA) and bioequivalence studies (BE)
Use of In silico Methodologies to Predict the Bioavailability of Oral Suspensions: A Regulatory Approach
Oral suspensions are heterogeneous disperse systems, and the particle size distribution, crystalline form of the dispersed solid, and composition of the formulation can be listed as parameters that control the drug dissolution rate and its bioavailability.
Automated covariate selection: SAMBA and COSSAC algorithms
COSSAC Conditional Sampling use for Stepwise Approach based on Correlation tests
SAMBA Stochastic Approximation for Model Building Algorithm
ISoP New Board of Trustees Members Announced
Amparo de la Peña, Vice President of Pharmacometrics at Simulations Plus, will join Jeff Sachs, Pavan Vaddady and Hao Zhu as new board members for 2024.
Contributed data, collaboration and experience with ionization models – Part 1. Bayer Pharmaceuticals
World‘s best in class pKa prediction tool
Utilizing pKa Values for Effective Crop Protection: On Systemicity and Efficacy of Molecules
pKa important factor in research screening cascade of molecules
November 2023 News/Events
Are your clinical trials showing potential liver toxicity?
Development of an Ocular PBPK-PD model to predict drug-mediated intraocular pressure reduction in preclinical species
Glaucoma, caused by an elevation of the intra-ocular pressure (IOP), leads to vision loss
The Keys to Making Good Models from Chemical Structures
There are many different things that make a model "good."
GastroPlus® v9.9 Product Brochure
GastroPlus is a mechanistically based simulation software backage that simulates intravenous, oral, oral cavity, ocular, inhalation, dermal, subcutaneous, and intramuscular absorption...