Confidence in FIH PBPK models

Authors: Miller N
Conference: SLP MIDD+
Keywords: fih prediction, FIHSimulator, Pre-Clinical, SLP2021MIDD
Division: Simulations Plus

To verify or not to verify, that is the question

  • “To be, or not to be, that is the question” is probably the best-known line from all drama, specifically it is from William Shakespeare’s play Hamlet
  • A well-known debate within the PBPK community is whether preclinical verification of a PBPK model gives more confidence in a FIH PBPK prediction…

By Neil Miller

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Presented at SLP MIDD+ Virtual Conference March 3-4, 2021