Please join us November 9th – 12th, in San Antonio, TX for AAPS PharmSci 360 and discover the latest in pharmaceutical science. Join researchers, industry leaders, and innovators for four days of cutting-edge sessions, networking, and career development across five dynamic scientific tracks. 

Members of our Simulations Plus team will be in attendance, so make sure to connect with them in booth #3635. 

Join us at Rx to Rock: Honky Tonk 
Date: Tuesday, November 11th
Time: 6:00-9:00 PM CST
Location: Lonestar C ballroom at the Grand Hyatt San Antonio

Registration is now open, RSVP today! 

We hope to see you there!

Can’t Miss Presentations! 

Symposium Session: Special Considerations for Patient Populations in Clinical Trials
Moderator – Viera Lukacova, Chief Scientific Officer
Track: Preclinical, Clinical, and Translational Sciences
Date/Time: Tuesday, November 11th | 9:00 – 11:00 AM
Location: 225 AB

• Title: Trial Design for Obesity: Right Compound, Right Dose, Right Patient
  Speaker: Maxime Le Merdy, Director, Scientific Product Enablement
  Date/Time: Tuesday, November 11th | 10:00 – 10:30 AM
• Title: Model-Informed Design of Clinical Trial in Patients with Renal Impairment
  Speaker: Viera Lukacova, Chief Scientific Officer
  Date/Time: Tuesday, November 11th | 10:30 – 11:00 AM

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Symposium Session: Accelerating Drug Development Through Digital Innovation 2
Track: Formulation & Delivery
Date/Time: Wednesday, November 12th | 9:00 – 11:00 AM
Location: Stars at Night B2/B3

• Title: Derisking Formulation Strategies Using PBBM: Mechanistic Case Studies on Evaluating Food Effects and Guiding Dissolution Specifications
  Speaker: Deanna Mudie, Senior Principal Scientist
  Date/Time: Wednesday, November 12, 2025 | 10:30 – 11:00 AM

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Hot Topic Session: Identifying Gaps and Pushing Boundaries in Mechanistic Dissolution Modeling
Track: Preclinical, Clinical, and Translational Sciences
Date/Time: Wednesday, November 12th | 1:30 – 2:30 PM
Location: 220
Moderator/Speaker: Deanna Mudie, Senior Principal Scientist

Dissolution is a key determinant of oral drug product bioavailability and therapeutic effectiveness, making it a common quality attribute of many poorly soluble drug products. A mechanistic understanding of dissolution aids in understanding key performance mechanisms and setting clinically relevant specifications as a function of variable drug product and physiological characteristics. This session will begin with a short overview of key assumptions limiting the effectiveness of classical dissolution models, followed by presentations by two researchers pushing these boundaries.

Additional Speakers: Yanxing Wang, Ph.D., Associate Professor, New Mexico State University and Jozef Al-Gousous, PhD, Lecturer and Adjunct Assistant Professor, Johannes Gutenberg University Mainz; Adjunct Assistant Professor of the University of Michigan

Poster Presentations 

PBPK-Based Prediction of Obesity-Mediated Changes in Small Molecule Pharmacokinetics
Presenter: Maxime Le Merdy, Director, Scientific Product Enablement
Date/Time: Monday, November 10th | 9:30-10:30 AM
Poster #: M0930-05-30

Predicting Aflibercept Local Exposure in Humans Using an Ocular PBPK Model
Presenter: Maxime Le Merdy, Director, Scientific Product Enablement
Date/Time: Monday, November 10th | 1:30-2:30 PM
Poster #: M1330-05-29

From in vitro dissolution testing to in vivo clinical pharmacokinetic prediction using PBPK models for oral cavity drug products
Presenter: Fiona Plait, Senior Principal Scientist
Date/Time: Monday, November 10th | 2:30-3:30 PM
Poster #: M1430-05-30

Population Balance Modeling of Aggregation in Long-Acting Injectable Formulations Integrated with PBPK
Presenter: James Mullin, Scientific Product Specialist
Date/Time: Tuesday, November 11th | 9:30-10:30 AM
Poster #: T0930-09-59

Modeling Metamorphosis: Advancing Dermal PBPK Modeling – A Metronidazole Case Study
Presenter: Maximo Pettarin, Postdoctoral Fellow
Date/Time: Tuesday, November 11th | 9:30-10:30 AM
Poster #: T0930-08-53

Physiologically Based Pharmacokinetic Simulations Using Transdermal Compartmental Absorption and Transit Model (TCAT) for RLS-1496 Dermal Preparations
Presenter: Tarang Vora, Senior Scientist II
Date/Time: Tuesday, November 11th | 12:30-1:30 PM
Poster #: T1230-09-61

Simulations Plus Attendees:

• Viera Lukacova – Chief Science Officer
• Grace Fraczkiewicz – Vice President, PBPK Services
• Maxime Le Merdy – Director, Scientific Product Enablement, Product Development
• Fiona Plait – Scientific Product Specialist, Product Development
• Daniela Silva Ryan – Sr. Scientific Product Specialist, Product Development
• James Mullin – Senior Principal Scientist, PBPK R&D  
• Deanna Mudie, Ph.D. – Senior Principal Scientist, PBPK R&D
• Arlene Padron – Senior Director, Business Development
• Dan O’Connor – Senior Director, Business Development
• Andrew Mueller – Director, Business Development
• Tom Sanderson – Director, Business Development  
• Nate Musser – Senior Director, Business Operations, Sales Administration
• Christiina Buchert – Senior Marketing Administrative Assistant, Marketing
• Tarang Vora – Senior Scientist II, Scientific Staff
• Maximo Pettarin – Postdoctoral Fellow, Product Development
• Revathi Chapa – Senior Scientist, Scientific Staff