Using DDDPlus™ to Predict in vivo API Exposure Levels

Authors: DiBella J, Mullin JM
Keywords: absorption, dddplus, dissolution, gastroplus, in vitro, PBBM modeling, PBPK, precipitation, regulatory interaction
Software: DDDPlus™
Division: Simulations Plus

There has been an increasing desire to incorporate mechanistic models of in vitro experiments to evaluate the interplay between dissolution, precipitation, and absorption kinetics and inform PBBM/PBPK simulations to define virtual ‘safe spaces’. In this webinar, learn how the combination of DDDPlus™ and GastroPlus® streamlines the translation of key insights from in vitro experiments to guide product development activities and, potentially, regulatory interactions. Learn more here: https://www.simulations-plus.com/software/dddplus/