2-DAY WORKSHOP  

Simulations Plus: From PK-PD Models to Simulations: A Hands-On Workshop using MonolixSuite™

Dates/Time: October 17th – 18th, 8:00 am – 5:00 pm

Description: This two-day interactive workshop will guide you through population PK-PD modeling, advanced model development strategies, and simulations using MonolixSuite. With hands-on exercises and discussions, it will provide practical skills to build, refine, and apply models effectively in your daily work. A temporary MonolixSuite license is included to continue applying what you learn beyond the workshop. Prior experience with MonolixSuite is not required.

What You Will Learn :

• Build and diagnose PK-PD models in Monolix® including data visualization, model definition and estimation.
• Optimize complex models understand the methods and algorithms behind each task and the impact of their settings.
• Set up simulation scenarios and efficiently answer “what if” questions using Simulx from comparing different dosing regimens and the impact of patient variability, to simulating clinical trial scenarios.
• Improve efficiency in modeling workflows o Apply best practices and automatization tools to streamline your work.

Join us to enhance your modeling and simulation skills and use MonolixSuite confidently in your projects!

Presenters:

• Monika Twarogowska – Applications Manager and Customer Relationship Coordinator, Clinical Pharmacology & Pharmacometrics Solutions
• Frano Mihaljevic – Applications Manager, Clinical Pharmacology & Pharmacometrics Solutions

1-DAY WORKSHOP

Simulations Plus: End-to-end clinical trial modeling with the Thales QSP software platform

Date/time: October 18th, 8:00 am – 5:00 pm

Description: This workshop provides an in-depth introduction to Thales, a cloud-based quantitative systems pharmacology (QSP) modeling platform with a focus on simulating virtual clinical trials. The 1-day session includes both lectures and hands-on exercises, aimed at familiarizing participants with the platform’s core functionalities and its use in translational and clinical modeling contexts. Lectures will cover key features of the platform, specifically highlighting standardization of model representation, fitting, and validation. Emphasis will be placed on the platform’s native support of virtual populations and ability to simultaneously optimize data spanning numerous therapeutic interventions, as well as the suite of integrated software tools that enable the design and execution of virtual clinical trials. Finally, the workshop will conclude with a preview of how Thales integrates AI, giving a glimpse into the future of QSP modeling. Practical sessions will allow participants to apply these concepts directly, using case-based examples relevant to current needs in model-informed drug development. Users will gain first-hand experience using the cloud-based platform in setting up simulations, using peripheral tools, and interpreting model outputs. The workshop is intended for modelers and scientists with experience working in QSP and interest in an end-to-end modeling platform for virtual trial simulation.

Presenters:

• Ryan Suderman – Director and Senior Principal Scientist, Quantitative Systems Pharmacology
• Cameron Meaney – Scientist I, Quantitative Systems Pharmacology
• Clifton Anderson – Scientist II, Quantitative Systems Pharmacology