Viera Lukacova

Viera Lukacova

Viera Lukacova, Ph.D.
CSO
Simulations Plus, Inc.

About Viera
Viera Lukacova is the Chief Scientific Officer at Simulations Plus, Inc. She’s been with the company for ~ 15 years working on the GastroPlus®, DDDPlus™, and MembranePlus™ software packages as well as contributing to modeling studies helping companies with their drug development programs in different stages of drug development process and interactions with regulatory agencies.

Latest Research by Viera Lukacova

05/01/2022

Clinical Ocular Exposure Extrapolation Using PBPK Modeling and Simulation: Moxifloxacin Solution Case Study

LeMerdy M, Lukacova V, Tan ML, Babiskin A, Zhao L

Keywords: mechanistic absorption models (MAM), moxifloxacin, ocular, PBPK modeling, pharmacokinetic (PK) dataSoftware: GastroPlus®Conference: ARVODivision: Simulations Plus

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03/27/2022

Modeling of Cyclosporine A-Induced Acute Kidney Injury with RENAsym®

Woodhead JL, Bhargava P, Battista C, Lukacova V

Keywords: Acute kidney injury (AKI), CsA, nephrotoxicity, QST, QST modeling, Quantitative Systems Toxicology (QST), RENAsym, RPTECSoftware: RENAsym™Conference: SOTDivision: DILIsym Services

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03/09/2022

Current status and gaps in mechanistic in-silico modeling for clinical translation and performance

Lukacova V

Keywords: active pharmaceutical ingredient (API), clinical translation & performance, in silico, PBPK modelSoftware: GastroPlus®Conference: AAPSDivision: Simulations Plus

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08/29/2021

Development of PBPK model for intra-articular injection in human: methotrexate solution and rheumatoid arthritis case study

LeMerdy M, Mullin JM, Lukacova V

Keywords: intra-articular, Methotrexate, PBPK, product development, rheumatoid arthritisSoftware: GastroPlus®Division: Simulations PlusPublication: J Pharmacokinet Pharmacodyn

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08/24/2021

PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-Glucuronosyltransferase Substrates

Reddy MB, Bolger MB, Fraczkiewicz G, Del Frari L, Luo L, Lukacova V, Mitra A, Macwan JS, Mullin JM, Parrott N, Heikkinen AT

Keywords: first pass extraction, gastroplus, gut metabolism, IVIVE, pbbm, PBPK modeling, translational science, ugt metabolismSoftware: ADMET Predictor®, GastroPlus®Division: Simulations PlusPublication: Pharmaceutics

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08/05/2021

Real-world Considerations in Pharma for QSP Modeling

Howell BA, Siler SQ, Yang K, Lukacova V, Padron A

Keywords: admet predictor, gastroplus, PBPK, QSP modeling, SimPopsSoftware: ADMET Predictor®, DILIsym®, GastroPlus®Division: DILIsym Services, Simulations Plus

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06/24/2021

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus

Szeto KX, LeMerdy M, Dupont D, Bolger MB, Lukacova V

Keywords: in silico, PBPK, pregnancy, renal clearanceSoftware: GastroPlus®Division: Simulations PlusPublication: AAPS J

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06/15/2021

Best Practices for Membrane & Biphasic In Vitro Dissolution with DDDPlus™ & GastroPlus®

Mullin JM, Lukacova V

Keywords: dddplus, gastroplus, in vitro dissolution, IVIVE, PBPK modelingSoftware: DDDPlus™, GastroPlus®Division: Simulations Plus

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04/27/2021

Human-on-a-Chip combined with PBPK modeling for in vitro/in vivo PK/PD extrapolation

Hickman J, Lukacova V

Keywords: drug-drug interactions (DDIs), gastroplus, Human-on-a-Chip (HoaC) systems, in vitro, PK predictionSoftware: GastroPlus®Division: Simulations Plus

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03/04/2021

Keynote: Women in Pharmaceutical Science

Fiedler-Kelly J, Lehmann L, Lukacova V, Suarez-Sharp S, Novakovic J, Graves B, Twarogowska M, Shoda LKM, Longo DM, Roberts JK

Keywords: main stage, SLP2021MIDD, WIS2021, women in scienceConference: SLP MIDD+Division: Simulations Plus

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