Absorption, Distribution, Metabolism, and Excretion of [14C]SHEN211, a Nonpeptidic Small-Molecule 3CLpro Inhibitor, in Rats

Absorption, Distribution, Metabolism, and Excretion of [14C]SHEN211, a Nonpeptidic Small-Molecule 3CLpro Inhibitor, in Rats

Publication: J Pharmacology Experimental Therapeutics
Software: GastroPlus®
Division: PBPK

SHEN211 is a selective 3-chymotrypsin-like protease inhibitor that can protect against severe acute respiratory syndrome coronavirus 2.

Tissue Distribution and Pharmacokinetic Characteristics of Aztreonam Based on Multi-Species PBPK Model

Tissue Distribution and Pharmacokinetic Characteristics of Aztreonam Based on Multi-Species PBPK Model

Publication: Pharmacokinetics and Pharmacodynamics
Software: GastroPlus®
Division: PBPK

As a monocyclic β-lactam antibiotic, aztreonam has regained attention recently because combining it with β-lactamase inhibitors helps fight drug-resistant bacteria.

Assessing Whether Breastfeeding is Safe After an Intraoral Injection of 68 mg of Articaine

Assessing Whether Breastfeeding is Safe After an Intraoral Injection of 68 mg of Articaine

Publication: J Am Dent Assoc
Software: GastroPlus®
Division: PBPK

Limited information is available about the transfer of articaine into breast milk and the associated risks to breastfed infants.

Using Model Master Files to Support Oral Drug Product Development and Regulatory Submissions

Using Model Master Files to Support Oral Drug Product Development and Regulatory Submissions

Publication: Pharm Res
Software: GastroPlus®
Division: PBPK

This report summarizes the proceedings of Session 2 of the two-day public workshop titled “Considerations and Potential Regulatory Applications for a Model Master File” hosted by the U.S. Food and Drug Administration (FDA) and the Center for Research on Complex Generics (CRCG) on May 2–3, 2024.

Intestinal Secretion Is a Potentially Important Clearance Mechanism for Low Metabolic Clearance Compounds

Intestinal Secretion Is a Potentially Important Clearance Mechanism for Low Metabolic Clearance Compounds

Publication: Journal of Medicinal Chemistry
Software: ADMET Predictor®
Division: Cheminformatics

Intestinal excretion/secretion (IE) from the systemic circulation via the enterocytes into the intestinal lumen has traditionally been considered a minor clearance (CL) pathway.

Framework for Classifying Chemicals for Repeat Dose Toxicity Using NAMs

Framework for Classifying Chemicals for Repeat Dose Toxicity Using NAMs

Publication: Regul Tox
Software: GastroPlus®
Division: PBPK

EPAA’s ‘NAM Designathon 2023’ challenge for human toxicity sought to identify a classification system capable of categorising chemicals based on their bioactivity and bioavailability properties determined using non-animal methodologies (Worth et al. 2025).

Multi-target Property Prediction and Optimization Using Latent Spaces of Generative Model

Multi-target Property Prediction and Optimization Using Latent Spaces of Generative Model

Publication: Mach Learn Sci Technol
Software: ADMET Predictor®
Division: Cheminformatics

Multi-target property prediction has the potential to improve generalization by exploiting the positive transfer between targets.

Investigation of the Suitability of Utilizing Plasma Concentration as a Surrogate to Understand Lung Exposure of Inhaled Drug in Rats: Different Delivery Methods of Fluticasone Propionate

Investigation of the Suitability of Utilizing Plasma Concentration as a Surrogate to Understand Lung Exposure of Inhaled Drug in Rats: Different Delivery Methods of Fluticasone Propionate

Publication: J Pharm Sci
Software: GastroPlus®
Division: PBPK

Pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD) are complex human airway diseases that affect millions of people worldwide.

From Lab-to-Clinic with Model Informed Formulation Development: a Case Study of Hydroxyzine SR Tablets

From Lab-to-Clinic with Model Informed Formulation Development: a Case Study of Hydroxyzine SR Tablets

Publication: Xenobiotica
Software: GastroPlus®
Division: PBPK

Model Informed Formulation Development (MIFD) uses physiologically based pharmacokinetic (PBPK) modelling and other in silico tools to facilitate new product development.

Model Integrated Evidence Approach for Rational and Safe Formulation Development: case of alfuzosin prolonged-release tablets

Model Integrated Evidence Approach for Rational and Safe Formulation Development: case of alfuzosin prolonged-release tablets

Publication: J Appl Pharm Sci
Software: GastroPlus®

The model integrated evidence (MIE) approach aims to utilize simulation tools like physiologically based biopharmaceutic model (PBBM) or physiologically based pharmacokinetic (PBPK) model for the development of new drugs and generic formulations.

Role of Physiologically Based Biopharmaceutics Modeling in Predicting and Circumventing the Drug-Drug Interactions of Tyrosine Kinase Inhibitors with Acid-Reducing Agents

Role of Physiologically Based Biopharmaceutics Modeling in Predicting and Circumventing the Drug-Drug Interactions of Tyrosine Kinase Inhibitors with Acid-Reducing Agents

Publication: J Appl Pharm Sci
Software: GastroPlus®
Division: PBPK

Tyrosine kinase inhibitors (TKIs) are molecular targeting agents used to treat various types of cancer. During the treatment with TKIs, acid-reducing agents (ARAs) are prescribed to prevent gastric mucosal damage.

Evaluation of Violacein Metabolic Stability and Metabolite Identification in Human, Mouse, and Rat Liver Microsomes

Evaluation of Violacein Metabolic Stability and Metabolite Identification in Human, Mouse, and Rat Liver Microsomes

Publication: Pharmaceutics
Software: ADMET Predictor®
Division: Cheminformatics

Malaria significantly impacts the health of populations living in poverty and vulnerable conditions. Resistance to current antimalarial drugs remains a major challenge and highlights the urgent need for novel, effective, and safer therapies.

An Ocular Exposure Prediction for Topical Atropine in Human Using Physiologically Based Pharmacokinetic Modeling

An Ocular Exposure Prediction for Topical Atropine in Human Using Physiologically Based Pharmacokinetic Modeling

Publication: AAPS J
Software: GastroPlus®
Division: PBPK

Developing a mathematical model to predict the distribution and bioavailability of atropine in human eyes is an insight approach for clinical practice.

Establishing Clinically Relevant Specifications for Carbamazepine Tablets Using Physiologically Based Pharmacokinetic Modeling

Establishing Clinically Relevant Specifications for Carbamazepine Tablets Using Physiologically Based Pharmacokinetic Modeling

Publication: AAPS J
Software: GastroPlus®
Division: PBPK

The purpose of this study was to establish a clinically relevant specification for carbamazepine (CBZ) tablets, a classic narrow therapeutic index drug (NTID), within the Chinese population.