The perioperative period, encompassing preoperative, intraoperative, and postoperative phases, is crucial for comprehensive patient care.
Regulation of Adipocyte Differentiation and Lipid Metabolism by Novel Synthetic Chromenes Exploring Anti-obesity and Broader Therapeutic Potential
Obesity poses a significant global health challenge, necessitating the search for novel therapeutic agents to address this epidemic.
Modeling and Simulation of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended-Release and Immediate-Release Formulations in Healthy Adults Using the Quantitative Systems Toxicology Software Platform DILIsym
Acetaminophen (APAP) has been formulated as immediate-, modified-, and extended-release tablets (APAP-IR, -MR, and -ER, respectively).
Avocado Fruit Peel as a Source of Antidiabetic drugs: Evidence from Molecular Docking Studies and ADMET Profiling
Diabetes mellitus is a long-term metabolic disorder characterized by persistent hyperglycemia, which can lead to various health problem if left untreated.
Monoaminergic Neurotransmitters are Bimodal Effectors of Tau Aggregation
Neurotransmitters (NTs) mediate trans-synaptic signaling, and disturbances in their levels are linked to aging and brain disorders.
Distinguishing Classes of Neuroactive Drugs Based on Computational Physicochemical Properties and Experimental Phenotypic Profiling in Planarians
Mental illnesses put a tremendous burden on afflicted individuals and society.
In vivo Performance of Amorphous Solid Dispersions Based on Water-Insoluble Versus Water-Soluble Carriers: Fenofibrate Case Study
The objective of this study is to address the unanswered question whether sustained supersaturation generated from amorphous solid dispersions (ASDs) formulated in insoluble hydrogel carriers will result in better bioavailability over that of spring-and-parachute type of dissolution profiles of ASDs formulated in water-soluble carriers
Development of the Pyrido[2,3-d]pyrimidin-7(8H)-one Scaffold toward Potent and Selective NUAK1 Inhibitors
The protein kinase NUAK1 has been implicated in various biological functions including cell adhesion, migration and proliferation.
Application of an Interdisciplinary Approach to Form Selection in Drug Development
Selecting the development form of an active pharmaceutical ingredient (API) in drug development is key to determining the final performance of the drug substance and drug product.
Physiologically Based Pharmacokinetic and Physiologically Based Biopharmaceutic Models Research in Latin America: A Regional Level Bibliometric Analysis, 2011-2023
The landscape of scientific research in Latin America (LA), particularly in the realms of the Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutic models (PBPM), is a mosaic of varied contributions, collaborations, and specializations.
Dosage Optimization Using Physiologically Based Pharmacokinetic Modeling for Pediatric Patients with Renal Impairment: A Case Study of Meropenem
The pharmacokinetics of renally eliminated antibiotics can be influenced by changes associated with renal function and development in a growing subject. Little is known about the effects of renal insufficiency on the pharmacokinetics of meropenem in pediatric subjects.
Association Between Abatacept Exposure Levels and Infection Occurrence in Patients with Rheumatoid Arthritis: Post Hoc Analysis of the AVERT-2 Study
To determine if higher serum exposure during subcutaneous (SC) abatacept treatment was associated with an increased infection risk in adult patients with early rheumatoid arthritis (RA).
Molecular Docking, ADMET, DFT Studies, and Retrosynthesis Strategy of New Benzimidazolone Derivatives as HIV-1 Reverse Transcriptase (RT) Inhibitors
HIV-1, or Human Immunodeficiency Virus type 1, is a global pandemic that affects millions of individuals worldwide.
Formulation Development and Evaluation, in silico PBPK Modeling and in vivo Pharmacodynamic Studies of Clozapine Matrix Type Transdermal Patches
Clozapine is a potent serotonin receptor antagonist and commonly used for the treatment of Schizophrenia.
Multi-Criteria Decision Analysis in Drug Discovery
Drug discovery is inherently a multi-criteria optimization problem.
Neuropharmacological Profile of New Thiazepinone and Thiazolidinone Compounds Designed by Virtual Screening
To evaluate the neuropharmacological profile of new spiro thiazepinone and thiazolidinone compounds in CD1 mice after a computer-aided virtual screening based on a GABA-A/BZD site.
Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients
Salbutamol, a short-acting β2-agonist used in asthma treatment, is available in multiple formulations, including inhalers, nebulizers, oral tablets, and intravenous, intramuscular, and subcutaneous routes.
Characterization of Preclinical Radio ADME Properties of ARV-471 for Predicting Human PK Using PBPK Modeling
Proteolysis-targeting chimeras (PROTACs) represent a promising class of drugs that can target disease-causing proteins more effectively than traditional small molecule inhibitors can, potentially revolutionizing drug discovery and treatment strategies.
In silico Model to Predict Dermal Absorption of Chemicals in Finite Dose Conditions
The development of in silico approaches that can estimate the dermal absorption of chemicals exposed in practical conditions is highly anticipated. In the present study, an in silico model to estimate both the dermal absorption rate and dermal permeation profile was developed for the application of chemicals in finite dose conditions.
Advancing Systemic Toxicity Risk Assessment: Evaluation of a NAM-based Toolbox Approach
For many years, a method that allowed systemic toxicity safety assessments to be conducted without generating new animal test data, seemed out of reach.