In recent years, global sensitivity analysis (GSA) has gained interest in physiologically based pharmacokinetics (PBPK) modelling and simulation from...
Impact of differential particle size of fenofibrate nanosuspensions on biopharmaceutical performance using physiologically based absorption modeling in rats
Particle size and its distribution governs oral biopharmaceutical performance of poorly water-soluble active pharmaceutical ingredients (APIs).
Pharmacokinetics of Intravenous, Intramuscular, Oral, and Transdermal Administration of Flunixin Meglumine in Pre-wean Piglets
Castration and tail-docking of pre-wean piglets are common procedures that are known to induce pain and would benefit from pain mitigation.
Predicting the mutagenic potential of chemicals in tobacco products using in silico toxicology tools
Tobacco products contain thousands of chemicals, including addictive and toxic chemicals.
Metabolism of N-ethylhexedrone and buphedrone: An in vivo study in mice using HPLC-MS/MS
N-ethylhexedrone (NEH) and buphedrone (BUPH) are synthetic drugs structurally related to natural cathinone.
Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones
There is a pressing need to improve the efficiency of drug development, and nowhere is that need more clear than in the case of neglected diseases...
Novel High-Drug-Loaded Amorphous Dispersion Tablets of Posaconazole; In Vivo and In Vitro Assessment
Amorphous solid dispersions (ASDs) can increase the bioavailability of drugs with poor aqueous solubility.
Profiling the antidepressant properties of phenyl piperidine derivatives as inhibitors of serotonin transporter (SERT) via cheminformatics modeling, molecular docking and ADMET predictions
The inhibition of serotonin transporter (SERT) has been considered to be a good target for the treatment of mood disorders (depression).
Predicting the effect of prandial stage and particle size on absorption of ODM-204
The prediction of absorption properties plays a key role in formulation development when the compound under development shows poor solubility...
Tyrosol 1,2,3-triazole analogues as new acetylcholinesterase (AChE) inhibitors
The present work proposed the preparation of triazolic analogues of tyrosol, a biophenol found in olive oil and whose wide range of bioactivities...
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies
Oral drug absorption is a complex process depending on many factors, including the physicochemical properties of the drug, formulation...
Morphological transition of M. tuberculosis and modulation of intestinal permeation by food grade cationic nanoemulsion: In vitro-ex vivo-in silico GastroPlus studies
The study aimed to investigate rifampicin (RIF) loaded cationic nanoemulsion (NE) for increased efficacy, facilitated intestinal...
GLORYx: Prediction of the Metabolites Resulting from Phase 1 and Phase 2 Biotransformations of Xenobiotics
Predicting the structures of metabolites formed in humans can provide advantageous insights for the development of drugs and other compounds.
In Silico studies of novel Sildenafil self-emulsifying drug delivery system absorption improvement for pulmonary arterial hypertension
Sildenafil is a potent selective inhibitor of phosphosdiesterase-5 previously used in erectile dysfunction and subsequently approved in 2005 for pulmonary...
Using a Physiologically Based Pharmacokinetic Absorption Model to Establish Dissolution Bioequivalence Safe Space for Oseltamivir in Adult and Pediatric Populations
Bioequivalence (BE) studies support the approval and clinical use of both new drug and generic drug products.
Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo consortium commentary
In vitro dissolution experiments are used to qualitatively assess the impact of formulation composition and process changes on the drug dosage form performance.
In silico Methods for Drug Design and Discovery
Computer-aided drug design (CADD) methodologies are playing an ever-increasing role in drug discovery that are critical in the cost-effective...
Identification and characterization of novel metabolites of nintedanib by ultra‐performance liquid chromatography/quadrupole time‐of‐flight tandem mass spectrometry with in silico toxicological assessment
Nintedanib, an oral, triple angiokinase inhibitor, is used alongside docetaxel in the management of locally recurrent non‐small‐cell lung cancer...
Forced degradation studies of medroxyprogesterone acetate injectable suspensions (150 mg/ml) with implementation of HPLC, mass spectrometry, and QSAR techniques
Medroxyprogesterone acetate (MPA) injectable products are a key commodity for reproductive health and are available in the global...
Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor
Chemicals have multiple effects in biological systems.