Semi-mechanistic modelling of the analgesic effect of gabapentin in the formalin-induced rat model of experimental pain

Semi-mechanistic modelling of the analgesic effect of gabapentin in the formalin-induced rat model of experimental pain

Publication: Pharm Res
Division: PBPK

The formalin-induced rat model of nociception involves moderate continuous pain. Formalin-induced pain results in a typical repetitive flinching behaviour, which displays a biphasic pattern characterised by peaks of pain.