Simulations Plus

In this presentation, Dr. Eric Martin of Novartis discusses improving bioavailability during lead optimization using global sensitivity analysis (GSA) of physiologically based pharmacokinetics.

In this webinar Dr. Stephen Ferguson of the National Institutes of Environmental Health Sciences discusses in silico approaches to predict human xenobiotic metabolism and their potential for human toxicity.

Learn about the new features in GastroPlus 8.6, how to build custom PBPK models for different disease states, and see a teaser of what's coming in version 9.0.

In this video, Dr. Viera Lukacova discusses how to get the most out of your in vitro permeability assays with MembranePlus™.

This video shows how MedChem Studio™ can be used to analyze percent inhibition data from a high-throughput screening experiment in order to identify candidates for further optimization.

This webinar is presented to provide details and answer questions concerning Simulations Plus' acquisition of Cognigen Corporation.

Following the success of our earlier NCE project, which focused on the design of antimalarial molecules, we sought to utilize our ADMET Design Suite™ to design novel compounds that inhibit both...

Predictive mechanistic simulation of gastric dissolution and in vivo supersaturation and precipitation during oral absorption, using experimental parameters derived from in vitro measurements.

An informative online webinar that discusses the application of absorption modeling as a biopharmaceutics risk assessment tool to facilitate Quality by Design (QbD) arguments during formulation development.

Learn about all the new features in ADMET Predictor 7.0 and how they can help you.

In this webinar, we present a new in silico multiprotic pKa prediction tool with upgraded functionality, improved prediction accuracy and significantly expanded applicability domain.

This webinar, hosted by the GastroPlus User Group, focuses on the simulation of in vivo dissolution and precipitation based on in vitro experimental data using GastroPlus, with the goal to provide better predictive oral absorption kinetics.

This webinar walks you through the new features and enhancements in GastroPlus version 8.5. Among the topics that will be covered: - new mechanistic model for in vivo precipitation kinetics...

This webinar discusses details of lead hopping and de novo design with MedChem Studio™, and demonstrates the software's ability to generate new virtual structures quickly and easily.

This webinar describes our modeling methodology and highlights the performance of key models. Special attention is devoted to our novel method of predicting macroscopic pKa, and our "Absorption Risk" Score.

The Metabolism Module in ADMET Predictor™ contains in silico models that classify compounds as substrates and/or inhibitors of the major CYP isoforms, while also predicting likely sites of metabolism and...

This webinar describes algorithms for the rapid and automatic extraction of Matched Molecular Pairs (MMPs) from large chemical data sets and for converting these pairs into structural transformation rules that...

Simulations Plus offers a rapidly growing array of accurate predictive models in ADMET Predictor™, focused on toxicity endpoints deemed important by regulatory agencies.

This webinar provides an introduction to an in silico lead optimization process that begins with high throughput screening data via class generation, R-group analysis, scaffold hopping, activity cliff detection...

This webinar by Dr. Robert Clark describes the in silico design, synthesis, and biological testing of novel antimalarial drug candidates generated by analysis of public HTS data.