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This Month In GastroPlus™ Modeling

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Visual variability check for population simulations

Do you modify liver blood flow values in GastroPlus PBPK models?

What are your preferred values for the Percent Fluid in SI & Colon in the ACAT model?

Effective GI permeability for pre-clinical species?

*note: must sign into LinkedIn and be a member of the GastroPlus User Group to review and contribute

New peer-reviewed journal publications citing various applications of GastroPlus software.

Physiologically-Based Pharmacokinetic Modeling in Lead Optimization I: Evaluation and Adaptation of GastroPlus to Predict Bioavailability of Medchem Series.

Physiologically-Based Pharmacokinetic Modeling in Lead Optimization II: “Rational Bioavailability Design” by Global Sensitivity Analysis to Identify Properties Affecting Bioavailability.

Preparation and Evaluation of Progesterone Nanocrystals to Decrease Muscle Irritation and Improve Bioavailability.

Clinical Bioavailability of the Novel BACE1 Inhibitor Lanabecestat (AZD3293): Assessment of Tablet Formulations Versus an Oral Solution and the Impact of Gastric pH on Pharmacokinetics.

Developing a mechanistic absorption model to predict the pharmacokinetics of immediate-release weak base drugs with a long Tmax by incorporating lysosomal trapping.

In vitro to in vivo extrapolation for high throughput prioritization and decision making.

Investigating Oral Absorption of Carbamazepine in Pediatric Populations.