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How well does GP predict brain PK in mice and more specifically in mdr1 -/- mice? Can rate of entry be predicted?

LogP

Food Effect Projections via Physiologically Based Pharmacokinetic Modeling: Predictive Case Studies

IVIVC level C

Question on simulation of re-dissolution of precipitated drug particles in GI tract

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New peer-reviewed journal publications citing various applications of GastroPlus software.Physiologically Based Absorption Modeling to Predict Bioequivalence of Controlled Release and Immediate Release Oral Products.Application of a Dynamic Fluid & pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus™.Integration of Precipitation Kinetics From an In vitro, Multicompartment Transfer System and Mechanistic Oral Absorption Modeling for Pharmacokinetic Prediction of Weakly Basic Drugs.Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERα covalent antagonist (SERCA).Prediction of ARA/PPI Drug-Drug Interactions at the Drug Discovery and Development Interface.