In Silico Absorption Analysis of Valacyclovir in Wildtype and Pept1 Knockout Mice Following Oral Dose Escalation

Authors: Yang B, Smith DE
Publication: Pharm Res
Keywords: Acyclovir, in situ permeability, in vivo pharmacokinetics, intestinal absorption, valacyclovir
Software: GastroPlus®

Purpose

We developed simulation and modeling methods to predict the in vivo pharmacokinetic profiles of acyclovir, following escalating oral doses of valacyclovir, in wildtype and Pept1knockout mice. We also quantitated the contribution of specific intestinal segments in the absorption of valacyclovir in these mice.