A PBPK model of the negative effect of chitosan on acyclovir absorption: The mucus-chitosan interaction

Authors: Bolger MB, García MA, Langguth P
Conference: AAPS
Keywords: gut metabolism, in silico, in vitro, liver metabolism, mechanistic oral absorption model, oral bioavailability, PBPK model
Software: GastroPlus®
Division: Simulations Plus

Purpose

A recent bioavailability study raises questions about the universality of the permeability enhancing effect of chitosan on poorly permeable
drugs. Unexpectedly, chitosan reduced the  bioavailability of acyclovir. The purpose of this  study was to establish a hypothesis that could be tested using a mechanistic oral absorption model  to help establish a possible mechanism for this result.

2018 AAPS Annual Meeting PharmSci 360, November 4-7, 2018, Washington, DC

By Michael B Bolger, Mauricio A. García, Peter Langguth