In the context of DNA damage, Checkpoint Kinase 1 (Chk1) mediates a checkpoint response which arrests the cell cycle and allows the cell to complete DNA repair and replication. LY2880070(LY) is a selective adenosine triphosphate-competitive inhibitor of Chk1. Chk1 overexpression has been found in a variety of cancers. The safety of patients who are CYP2D6 poor metabolizers is an important consideration.
By Wilson H. Miller, Jr., Quincy Chu, Nathaniel Bouganim, Derek Jonker, Gerald Batist, Najwa Buhlaiga, Stephanie Lehureux, Jennifer Spratlin, Thierry Alcindor, Patricia S. Smith, Joel Owen, Sara Zaknoen, John R. Stille, Caroline Fortier, Darcy Vincett and Amit Oza presented at the American Society of Clinical Oncology’s (ASCO) Annual Meeting; May 29-31 2020; Virtual.