Many major enhancements have been made throughout ADMET Predictor for this release. The biggest is that version 8.5 includes a next-generation HTPK Simulation Module for estimating fraction absorbed, fraction bioavailable and the dose required to achieve a target plasma concentration. There have also been significant improvements to the interface, ADMET property models, MedChem Studio™ module, MedChem Designer™ and ADMET Modeler™, as well as numerous bug fixes.