Applicability of Existing Prediction Methods to Non-Oral Routes of Delivery

Authors: Lukacova V
Conference: AAPS
Software: GastroPlus®
Division: Simulations Plus


  • Significant progress was made in development of in vitro systems and models to predict intestinal absorption
  • Similarities in processes impacting absorption from oral and non-oral routes of delivery provide path towards improved predictions from non-oral routes of delivery
  • Additional route-specific processes impact predictions for non-oral routes of delivery:
  • Deposition with inhaled administration
  • Evaporation and impact of excipients on drug absorption with dermal administration
  • Potential aggregation and physiological response with IM or SC injectables
  • Contribution of intestinal absorption with oral cavity, ocular, and inhaled administration

By Viera Lukacova

Presented at American Association of Pharmaceutical Scientists (AAPS) PharmSci 360, October 17-20, 2021