Assessing the Role of Intracellular Binding Protein in Drug-Induced Bile Acid Transporter Inhibition Using QuantiativeSystems Pharmacology (QSP) Modeling
Keywords: bile acid (BA) homeostasis, bile salts, drug-induced liver injury, Quantitative Systems Toxicology (QST)Software: DILIsym®Conference: AAPSDivision: DILIsym Services
Introduction
DILIsym Is Used to Predict Bile-Acid Mediated Drug-Induced Liver Injury
- DILIsym is a quantitative systems toxicology (QST) model of drug-induced liver injury (DILI)
- DILIsym has a good record of predicting DILI, including with drugs that are inhibitors of the bile salt export pump (BSEP)
- Bosentan/telmisartan
- Troglitazone/pioglitazone
- Tolvaptan
- TAK-875
- Kidetermined from a vesicle assay is used to represent inhibition potency in the simulation
2018 AAPS Annual Meeting PharmSci 360, November 4-7, 2018, Washington, DC
By Jeffrey L. Woodhead
