What are the so-called “nonlinearities” in pharmacokinetics (PK) for multiple dosage of oral drugs? What are their causes and implications? While developing the Simulation Module  – an in silico tool for conducting PK simulations based on the Advanced Compartmental Absorption and Transit (ACAT™) model  – we have discovered a handful of interesting cases of nonlinear PK behavior.
251st ACS National Meeting & Exposition, March 13-17, 2016, San Diego, CA
By Robert Fraczkiewicz, Michael B. Bolger, Walter S. Woltosz