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Mar 13, 2016
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Beyond IC50 and simple PK models – Considerations for discovery chemists

Introduction

What are the so-called “nonlinearities” in pharmacokinetics (PK) for multiple dosage of oral drugs? What are their causes and implications? While developing the Simulation Module [1] – an in silico tool for conducting PK simulations based on the Advanced Compartmental Absorption and Transit (ACAT™) model [2] – we have discovered a handful of interesting cases of nonlinear PK behavior.

251st ACS National Meeting & Exposition, March 13-17, 2016, San Diego, CA

By Robert Fraczkiewicz, Michael B. Bolger, Walter S. Woltosz

 

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