Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels

Authors: Jones HM, Butt RP, Webster R, Gurrell IK, Dzygiel P, Flanagan N, Fraier D, Hay TL, Iavarone LE, Luckwell J, Pearce H, Phipps A, Segelbacher J, Speed B, Beaumont K
Publication: Clin Pharmacokinet
Software: GastroPlus®

Background

The emergence of genetic data linking Nav1.7 sodium channel over- and under- expression to human pain signalling has led to an interest in the treatment of chronic pain through inhibition of Nav1.7 channels.