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Jun 23, 2022
  |  Presentation

Data required to build a fit-for-purpose PBPK model: How much is necessary?

PBPK M&S and PBBM

  • PBPK Modeling: Physiologically Based Pharmacokinetic Modelling
    • A mathematical modelling technique for predicting the ADME of synthetic or natural chemical substances in humans and other animal species
  • PBBM: Physiologically Based Biopharmaceutics Modelling
    • Establishing the link between bio-predictive in vitro dissolution testing and mechanistic oral absorption modeling
    • Mechanistic implementation of formulation/manufacturing aspects that are relevant to dissolution/release from the drug product
    • Verifying whether the dissolution method of the pharmaceutical product is bio-predictive or clinically relevant

By Anant Kektar

Presented at DISSO India June 23-25, 2022

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