Delineating the Complex Interplay of Enzymes and Transporters Governing the Absorption and Disposition of Atorvastatin and the Metabolites Using Physiologically Based Pharmacokinetic (PBPK) Modeling

Conference: ISSX
Software: GastroPlus®
Division: Simulations Plus


Atorvastatin (ATS) is widely used to treat high cholesterol and potentially lower the risk of cardiac complications. Absorption and disposition of atorvastatin and the metabolites 2-hydroxy atorvastatin (2-OH ATS), 4-hydroxy atorvastatin (4-OH ATS) and atorvastatin lactone (AL) is governed by complex interplay of multiple enzymes and transporters.

By Revathi Chapa and Grace Fraczkiewicz

Presented at ISSX/MDO 2022, September 11-14, 2022, Seattle, WA