Atorvastatin (ATS) is widely used to treat high cholesterol and potentially lower the risk of cardiac complications. Absorption and disposition of atorvastatin and the metabolites 2-hydroxy atorvastatin (2-OH ATS), 4-hydroxy atorvastatin (4-OH ATS) and atorvastatin lactone (AL) is governed by complex interplay of multiple enzymes and transporters.
By Revathi Chapa and Grace Fraczkiewicz
Presented at ISSX/MDO 2022, September 11-14, 2022, Seattle, WA
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