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Mar 27, 2018
  |  Webinar

Discovery PBPK: How to enhance the expected accuracy of bioavailability predictions for NCEs that are not primarily metabolized

In this webinar, we will review the accuracy of purely in silico estimates of bioavailability and the chemistry classification of new chemical entity (NCE) molecules that are easier or harder to accurately estimate using in silico or in vitro data. We will also introduce a novel Discovery PBPK method of local clearance modeling to enhance accuracy for bioavailability estimates for molecules that do not have metabolism as a primary mechanism of systemic clearance.

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