Dynamic Dissolution Testing To Establish In Vitro/In Vivo Correlations for Montelukast Sodium, a Poorly Soluble Drug

Authors: Okumu A, DiMaso M, Loebenberg R
Publication: AAPS J
Keywords: Advanced Compartmental Absorption and Transit (ACAT™) model, body condition score (BCS), computer simulation, dynamic dissolution, in vitro-in vivo correlation (IVIVC), montelukast sodium
Software: GastroPlus®

Purpose

The objectives of the study was to develop a dissolution test method that can be used to predict the oral absorption of montelukast sodium, and to establish an in vitro/in vivo correlation (IVIVC) using computer simulations.